INT262216

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2, Vdr) DNA binding (Nr1i2, Vdr) cytosol (Vdr)
cell morphogenesis (Vdr)
Nr1i2 (Mus musculus)
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 1 78.84 Quite High
antiepileptic Drug 1 76.68 Quite High
Bile 39 34.28 Quite Low
agonist 9 12.68 Low Low
Inflammation 17 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 8 95.76 Very High Very High Very High
Metabolic Bone Disease 1 82.12 Quite High
Toxicity 4 28.28 Quite Low
Targeted Disruption 17 16.36 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pascussi et al. first suggested that activation of SXR can enhance the expression of the VDR target gene, CYP24, which would increase the catabolism of 1,25(OH)2D3; thereby, leading to drug-induced osteomalacia [Pascussi et al., 2005].
Positive_regulation (activation) of SXR Positive_regulation (enhance) of Gene_expression (expression) of VDR associated with rickets
1) Confidence 0.29 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0.08

General Comments

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