INT262223

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4) enzyme binding (CYP3A4)
DNA binding (Nr1i2) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
Nr1i2 (Mus musculus)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 3 92.00 High High
Breast Cancer 8 82.96 Quite High
Cancer 18 69.08 Quite High
Apoptosis 5 60.80 Quite High
Osteogenic Sarcomas 5 33.28 Quite Low
Targeted Disruption 17 12.24 Low Low
Colon Cancer 2 10.64 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, SXR downregulation would reduce expression of CYP3A4, thereby increasing local estrogen levels and/or increasing sensitivity of estrogen receptor to estradiol [Cheng et al., 2001].
Negative_regulation (downregulation) of SXR Negative_regulation (reduce) of Gene_expression (expression) of CYP3A4
1) Confidence 0.21 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.48 Pain Relevance 0

General Comments

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