INT262224

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Sfn, CYP3A4) small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) extracellular region (Sfn)
Anatomy Link Frequency
hepatocytes 2
Sfn (Mus musculus)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 96.68 Very High Very High Very High
Versed 2 85.76 High High
Bile 78 5.00 Very Low Very Low Very Low
Inflammation 34 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 36 95.08 Very High Very High Very High
Apoptosis 10 75.52 Quite High
Adverse Drug Reaction 2 50.96 Quite High
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Osteoporosis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SFN efficiently inhibits SXR-mediated transcription of the CYP3A4 gene in a concentration-dependent manner.
SFN Negative_regulation (inhibits) of Transcription (transcription) of CYP3A4
1) Confidence 0.06 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.27 Pain Relevance 0.13
Interestingly, it has also been reported that SFN downregulated CYP3A4 transcription and enzymatic activity in cultured human hepatocytes, suggesting another mechanism that could also contribute to its anti-cancer effects [Maheo et al., 1997].
SFN Negative_regulation (downregulated) of Transcription (transcription) of CYP3A4 in hepatocytes associated with cancer
2) Confidence 0.06 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.31 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox