INT262229

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) small molecule metabolic process (CYP3A4) oxidoreductase activity (CYP3A4)
endoplasmic reticulum (CYP3A4) plasma membrane (Casr) enzyme binding (CYP3A4)
Anatomy Link Frequency
CAR 2
CYP3A4 (Homo sapiens)
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 78 70.72 Quite High
Inflammation 34 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 34 95.68 Very High Very High Very High
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Osteoporosis 14 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was subsequently shown that CAR only exhibits very weak binding and functional activation of the CYP3A4 promoter, instead showing a pronounced selectivity for CYP2B6 over CYP3A4 [Faucette et al., 2006].
CYP3A4 Binding (binding) of CAR in CAR
1) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.19 Pain Relevance 0.12
It was subsequently shown that CAR only exhibits very weak binding and functional activation of the CYP3A4 promoter, instead showing a pronounced selectivity for CYP2B6 over CYP3A4 [Faucette et al., 2006].
CYP3A4 Binding (binding) of CAR in CAR
2) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.19 Pain Relevance 0.13

General Comments

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