INT262232

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4) enzyme binding (CYP3A4)
DNA binding (Nr1i2) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
Anatomy Link Frequency
hepatocytes 2
Nr1i2 (Mus musculus)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Versed 1 99.60 Very High Very High Very High
antagonist 7 91.28 High High
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 18 85.44 High High
Adverse Drug Reaction 1 64.40 Quite High
Apoptosis 5 54.28 Quite High
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Targeted Disruption 17 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Rickets 8 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SFN inhibited SXR-mediated CYP3A4 expression and CYP3A4-mediated midazolam (MDZ) clearance in human primary hepatocytes.
SXR Positive_regulation (mediated) of Gene_expression (expression) of CYP3A4 in hepatocytes associated with versed
1) Confidence 0.17 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.26 Pain Relevance 0.14

General Comments

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