INT262284

Context Info Confidence 0.06 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0.31

transmembrane transporter activity (Slc22a6) plasma membrane (Slc22a6) protein complex (Slc22a6)

Slc22a6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat methotrexate 2 98.48 cINOD 1 97.92 aspirin 1 96.24 ischemia 1 83.80 vincristine 1 68.12 Bile 1 32.56 Morphine 5 7.60 Patient controlled alalgesia 2 5.00 Codeine 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Injury 92 100.00 INFLAMMATION 3 97.20 Cv Unclassified Under Development 1 83.80 Renal Disease 6 31.12 Chronic Renal Failure 8 5.52 Critical Illness 7 5.00 Uremia 4 5.00 Disease 3 5.00 Hypoxia 2 5.00 Liver Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the role played by OATs in nonrenal drug clearance has not been characterized, decreased OAT1 and OAT3 activity as a result of AKI could decrease the renal secretion of drugs such as methotrexate, nonsteroidal anti-inflammatory drugs, and acetylsalicylic acid [16].

Negative_regulation (decrease) of Positive_regulation (result) of OAT1 associated with aspirin, inflammation, injury, cinod and methotrexate

1) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.79 Pain Relevance 0.31

General Comments

This test has worked.