INT262286

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.26

transmembrane transporter activity (Slc22a6) plasma membrane (Slc22a6) protein complex (Slc22a6)

Slc22a6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 1 99.06 methotrexate 2 83.00 vincristine 1 82.44 cINOD 1 66.56 aspirin 1 63.20 Bile 1 46.88 Morphine 5 5.00 Patient controlled alalgesia 2 5.00 Codeine 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 1 99.06 Injury 92 98.82 INFLAMMATION 3 65.12 Heart Rate Under Development 1 5.16 Chronic Renal Failure 8 5.00 Critical Illness 7 5.00 Renal Disease 6 5.00 Uremia 4 5.00 Disease 3 5.00 Hypoxia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Induction of AKI in ischemia-reperfusion rat models demonstrates decreased OAT1 and OAT3 mRNA as well as protein expression [34-36].

Transcription (expression) of OAT1 associated with ischemia and injury

1) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.58 Pain Relevance 0.26

General Comments

This test has worked.