INT26229

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.10
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sensory neurons 1
synapses 1
microglia 1
ATP8A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nociceptor 4 99.84 Very High Very High Very High
Lasting pain 1 99.62 Very High Very High Very High
Inflammation 2 99.52 Very High Very High Very High
Brush evoked pain 2 99.16 Very High Very High Very High
Glutamate 4 99.08 Very High Very High Very High
bradykinin 1 98.76 Very High Very High Very High
b2 receptor 1 98.16 Very High Very High Very High
Calcitonin gene-related peptide 16 98.04 Very High Very High Very High
Pain 14 97.16 Very High Very High Very High
ASIC 1 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 9 99.62 Very High Very High Very High
INFLAMMATION 2 99.52 Very High Very High Very High
Neuropathic Pain 2 99.16 Very High Very High Very High
Ganglion Cysts 9 93.24 High High
Headache 2 92.72 High High
Nociception 4 86.20 High High
Glioma 3 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses.
Positive_regulation (Activation) of ATP in synapses associated with glutamate
1) Confidence 0.67 Published 1997 Journal Nature Section Title Doc Link 9338789 Disease Relevance 0.76 Pain Relevance 0.92
We also found that tactile allodynia under the chronic pain state requires an activation of P2X4 ionotropic ATP receptor and p38 mitogen-activated protein kinase in spinal microglia.
Positive_regulation (activation) of ATP in microglia associated with brush evoked pain and lasting pain
2) Confidence 0.67 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467256 Disease Relevance 0.37 Pain Relevance 0.46
PMA at a non-stimulatory concentration (2 ng/ml) potentiated the effect of fMet-Leu-Phe but did not induce responsiveness to PAF, ATP or beta-endorphin.
Neg (not) Positive_regulation (induce) of ATP
3) Confidence 0.49 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2552328 Disease Relevance 0 Pain Relevance 1.15
The differences in the characteristics of ATP-caused P1 hydrolysis and [Ca2+]i rise suggest that ATP receptors are independently coupled to phospholipase C and receptor-gated Ca2+ channels.
Positive_regulation (coupled) of ATP
4) Confidence 0.49 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8389991 Disease Relevance 0.22 Pain Relevance 0.12
Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide.
Positive_regulation (upregulation) of ATP in sensory neurons associated with nociceptor and calcitonin gene-related peptide
5) Confidence 0.49 Published 2006 Journal J. Neurosci. Section Title Doc Link 16763024 Disease Relevance 0.43 Pain Relevance 1.17
The progresses of molecular biology have once again enriched this peripheral inflammatory mix, which composition becomes more and more complicated: ATP and P2X3 purinergic receptor, bradykinin and B2 bradykinin receptor, H+ and ASIC proton receptor, vanilloïd receptor activated by heat, inflammation and increase in synthesis of sodic channels resistant to the tetradotoxine (TTXr)....
Positive_regulation (becomes) of ATP associated with inflammation, b2 receptor, bradykinin and asic
6) Confidence 0.45 Published 2003 Journal Nephrologie Section Abstract Doc Link 14650754 Disease Relevance 0.32 Pain Relevance 0.66

General Comments

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