INT262293

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 44.64
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (CC2D1A) microtubule organizing center (CC2D1A) cytoplasm (CC2D1A)
signal transducer activity (CC2D1A) signal transduction (CC2D1A) nucleolus (CC2D1A)
Anatomy Link Frequency
blood 4
kidney 2
organ systems 1
CC2D1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 99.06 Very High Very High Very High
Paracetamol 30 95.92 Very High Very High Very High
Dopamine 165 93.24 High High
cva 15 90.24 High High
aspirin 20 89.72 High High
cINOD 100 88.68 High High
methotrexate 10 87.16 High High
Inflammatory mediators 5 84.32 Quite High
chemokine 5 83.20 Quite High
cytokine 20 82.72 Quite High
Disease Link Frequency Relevance Heat
Injury 4970 100.00 Very High Very High Very High
Hypoxia 445 100.00 Very High Very High Very High
Necrosis 350 100.00 Very High Very High Very High
Nephrotoxicity 50 99.78 Very High Very High Very High
INFLAMMATION 250 99.06 Very High Very High Very High
Rhabdomyolysis 70 99.02 Very High Very High Very High
Burns 20 98.38 Very High Very High Very High
Congenital Anomalies 20 98.32 Very High Very High Very High
Sepsis 110 98.24 Very High Very High Very High
Renal Disease 865 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
the incidence of AKI is decreasing: true or falsegenetic factors may play a role in the susceptibility to AKI: true or falsehypoxic/ischemic AKI is a rare cause of AKI in children: true or falsenonsteroidal anti-inflammatory therapy is a risk factor for AKI in newborns: true or falseDiagnosis and etiology of AKI in children
Gene_expression (true) of AKI associated with inflammation and injury
1) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.26 Pain Relevance 0.05
alterations in blood flow are not thought to play a role in hypoxic/ischemic AKI: true or falsereactive oxygen molecules generated by activated PMNs may play a role in hypoxic/ischemic ATN: true or falseATP depletion is an early response to hypoxic/ischemic AKI: true or falsehypoxic/ischemic AKI is always reversible and has no long-term consequences: true or falseManagement of AKI in children
Gene_expression (falseManagement) of AKI in blood associated with necrosis, hypoxia and injury
2) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.68 Pain Relevance 0.08
Epidemiology studies of AKI in children has shown that
Gene_expression (studies) of AKI associated with injury
3) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.06 Pain Relevance 0.04
alterations in blood flow are not thought to play a role in hypoxic/ischemic AKI: true or falsereactive oxygen molecules generated by activated PMNs may play a role in hypoxic/ischemic ATN: true or falseATP depletion is an early response to hypoxic/ischemic AKI: true or falsehypoxic/ischemic AKI is always reversible and has no long-term consequences: true or falseManagement of AKI in children
Gene_expression (ischemic) of AKI in blood associated with necrosis, hypoxia and injury
4) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.34 Pain Relevance 0.07
Thus, administration of medications that can interfere with compensatory mechanisms to maintain renal perfusion can precipitate AKI in certain clinical circumstances.
Gene_expression (precipitate) of AKI associated with injury
5) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.50 Pain Relevance 0.16
the definition of AKI in children is well established: true or falsethe serum creatinine is a sensitive marker of AKI: true or falsein utero exposure to ACE inhibitors is associated with AKI in neonates: true or falseAKI in hospitalized children may be the result of multiple etiologies: true or falseurinary sodium concentration is a reliable indicator of pre-renal versus hypoxic/ischemic AKI in premature newborns: true or falseHypoxic/ischemic AKI
Gene_expression (ischemic) of AKI associated with hypoxia and injury
6) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.32 Pain Relevance 0.07
Aminoglycoside nephrotoxicity typically presents with nonoliguric AKI, with urinalysis showing minimal urinary abnormalities.
Gene_expression (presents) of AKI associated with nephrotoxicity, congenital anomalies and injury
7) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.62 Pain Relevance 0.13
the incidence of AKI is decreasing: true or falsegenetic factors may play a role in the susceptibility to AKI: true or falsehypoxic/ischemic AKI is a rare cause of AKI in children: true or falsenonsteroidal anti-inflammatory therapy is a risk factor for AKI in newborns: true or falseDiagnosis and etiology of AKI in children
Gene_expression (incidence) of AKI associated with inflammation and injury
8) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.11 Pain Relevance 0.05
neonates, infants, children and adolescents who have recovered from AKI do not need long-term follow up: true or falseAKI that occurs before nephrogenesis is complete may lead to later CKD: true or false



Gene_expression (true) of falseAKI associated with chronic renal failure and injury
9) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.46 Pain Relevance 0.04
alterations in blood flow are not thought to play a role in hypoxic/ischemic AKI: true or falsereactive oxygen molecules generated by activated PMNs may play a role in hypoxic/ischemic ATN: true or falseATP depletion is an early response to hypoxic/ischemic AKI: true or falsehypoxic/ischemic AKI is always reversible and has no long-term consequences: true or falseManagement of AKI in children
Gene_expression (ischemic) of AKI in blood associated with necrosis, hypoxia and injury
10) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.69 Pain Relevance 0.08
the incidence of AKI is decreasing: true or falsegenetic factors may play a role in the susceptibility to AKI: true or falsehypoxic/ischemic AKI is a rare cause of AKI in children: true or falsenonsteroidal anti-inflammatory therapy is a risk factor for AKI in newborns: true or falseDiagnosis and etiology of AKI in children
Gene_expression (ischemic) of AKI associated with inflammation and injury
11) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.14 Pain Relevance 0.05
the definition of AKI in children is well established: true or falsethe serum creatinine is a sensitive marker of AKI: true or falsein utero exposure to ACE inhibitors is associated with AKI in neonates: true or falseAKI in hospitalized children may be the result of multiple etiologies: true or falseurinary sodium concentration is a reliable indicator of pre-renal versus hypoxic/ischemic AKI in premature newborns: true or falseHypoxic/ischemic AKI
Gene_expression (ischemic) of AKI associated with hypoxia and injury
12) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.32 Pain Relevance 0.07
Children who have suffered AKI from any cause are at risk for late development of kidney disease several years after the initial insult.
Gene_expression (suffered) of AKI in kidney associated with renal disease and injury
13) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Abstract Doc Link PMC2756346 Disease Relevance 1.89 Pain Relevance 0.09
alterations in blood flow are not thought to play a role in hypoxic/ischemic AKI: true or falsereactive oxygen molecules generated by activated PMNs may play a role in hypoxic/ischemic ATN: true or falseATP depletion is an early response to hypoxic/ischemic AKI: true or falsehypoxic/ischemic AKI is always reversible and has no long-term consequences: true or falseManagement of AKI in children
Gene_expression (falseManagement) of AKI in blood associated with necrosis, hypoxia and injury
14) Confidence 0.40 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.17 Pain Relevance 0.08
Further validation and utilization of pRIFLE criteria would allow inter-center comparisons to be made of AKI in children.
Gene_expression (made) of AKI associated with injury
15) Confidence 0.36 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.45 Pain Relevance 0
There is growing evidence that specific disease states such as sepsis, burns, and trauma also influence CYP and transporter activity, independent of whether AKI is also present.
Gene_expression (present) of AKI associated with burns, injury, disease and sepsis
16) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.45 Pain Relevance 0.13
Disposition of formed metabolites in AKI
Gene_expression (Disposition) of AKI associated with injury
17) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.83 Pain Relevance 0.26
However, our understanding of AKI is continuously evolving, including an appreciation of the changes in drug pharmacokinetics and pharmacodynamics that occur with AKI.
Gene_expression (understanding) of AKI associated with injury
18) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.85 Pain Relevance 0
However, what is not well understood is the effect that AKI has on the clearance of these substances by other organ systems (nonrenal clearance).
Gene_expression (has) of AKI in organ systems associated with injury
19) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.90 Pain Relevance 0
Furthermore, as shown in Table 3, not all hepatic cytochrome P450 (CYP) enzymes are affected by AKI, and the extent of the effect on hepatic clearance via CYP may depend on the mechanism of experimental kidney injury.
Gene_expression (affected) of AKI in kidney associated with injury
20) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.39 Pain Relevance 0

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