INT26233

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 18.22
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
nucleus 3
MDA-MB-231 2
blood cells 2
CAR 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 75 100.00 Very High Very High Very High
agonist 52 99.12 Very High Very High Very High
cytokine 158 98.72 Very High Very High Very High
Inflammation 431 98.28 Very High Very High Very High
Inflammatory mediators 50 97.20 Very High Very High Very High
cINOD 41 95.12 Very High Very High Very High
dexamethasone 58 93.72 High High
Kinase C 13 93.44 High High
antagonist 13 92.80 High High
tolerance 43 89.48 High High
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 90 99.68 Very High Very High Very High
Skin Cancer 56 99.26 Very High Very High Very High
Brain Hemorrhage 12 99.24 Very High Very High Very High
Asthma 141 98.68 Very High Very High Very High
Disease 123 98.52 Very High Very High Very High
INFLAMMATION 568 98.28 Very High Very High Very High
Repression 14 98.26 Very High Very High Very High
Shock 4 98.08 Very High Very High Very High
Manic Depressive Disorder 22 97.56 Very High Very High Very High
Obesity 35 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Matsubara and colleagues recently found evidence of reduced mRNA expression of GR-alpha (the GR isoform which binds glucocorticoids) in peripheral blood cells of patients with bipolar disorder and in patients with major depressive disorder, both while depressed as well as in remission.
GR Binding (binds) of in blood cells associated with depression and manic depressive disorder
1) Confidence 0.46 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.94 Pain Relevance 0.03
The GC-independent repression of AP-1 and NF-kappa B activities was further demonstrated by overexpressing a ligand-binding deficient GR mutant.
GR Binding (binding) of associated with repression
2) Confidence 0.44 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.68 Pain Relevance 0.31
After binding to the glucocorticoid receptor (GR), they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP-1 and NF-kappa B.
GR Binding (binding) of associated with cytokine
3) Confidence 0.44 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.57 Pain Relevance 0.24
Matsubara and colleagues recently found evidence of reduced mRNA expression of GR-alpha (the GR isoform which binds glucocorticoids) in peripheral blood cells of patients with bipolar disorder and in patients with major depressive disorder, both while depressed as well as in remission.
GR Binding (binds) of in blood cells associated with depression and manic depressive disorder
4) Confidence 0.34 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.99 Pain Relevance 0.03
The latter includes binding of GR to a DNA-bound activator (tethering mechanism) or formation of abortive complex between GR and another transcription factor (squelching mechanism) [78].
GR Binding (formation) of
5) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.11 Pain Relevance 0.11
Similarly, binding of glucocorticoids to the GR-stimulated phosphatidylinositol 3-kinase and protein kinase Akt, leading to endothelial NOS activation and nitric oxide dependent vasorelaxation, is the mechanism by which glucocorticoids decreased vascular inflammation and reduced myocardial infarct size following ischaemia/reperfusion injury in mice [103].



GR Binding (binding) of associated with reperfusion injury, inflammation, cv unclassified under development, vasculitis and myocardial infarction
6) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.68 Pain Relevance 0.15
The GR directly activates or represses target genes by binding to hormone response elements in promoter or enhancer regions and by binding to other DNA sequence specific activators, and it can inhibit the transcriptional activities of other classes of transcription factors by transrepression.
GR Binding (binding) of
7) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.07 Pain Relevance 0
The GR directly activates or represses target genes by binding to hormone response elements in promoter or enhancer regions and by binding to other DNA sequence specific activators, and it can inhibit the transcriptional activities of other classes of transcription factors by transrepression.
GR Binding (binding) of
8) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.07 Pain Relevance 0
GR interactions with the other proteins of the complex are still poorly understood.
GR Binding (interactions) of
9) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.16 Pain Relevance 0
NIM, but not NAP, markedly increased MAPK phosphorylation (suggesting an increase in MAPK cascade activity), GR phosphorylation, GR binding to GRE, and transcriptional activation of MMTV promoter through the GRE site in the promoter.
GR Binding (binding) of
10) Confidence 0.27 Published 1999 Journal Arthritis Rheum. Section Body Doc Link 9920026 Disease Relevance 0 Pain Relevance 0
NIM, but not NAP, markedly increased MAPK phosphorylation (suggesting an increase in MAPK cascade activity), GR phosphorylation, GR binding to GRE, and transcriptional activation of MMTV promoter through the GRE site in the promoter.
GR Binding (binding) of
11) Confidence 0.26 Published 1999 Journal Arthritis Rheum. Section Body Doc Link 9920026 Disease Relevance 0 Pain Relevance 0
Most of the studies showing GR downregulation also found decreased cytosolic GR binding, which may result from compartmentalization of the GR during the acute response to cytokines.
GR Binding (binding) of associated with cytokine
12) Confidence 0.23 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.81 Pain Relevance 0.25
-induced blockade of GR transactivation by binding to nuclear receptor binding domain of GR-interacting protein 1.
GR-interacting Binding (binding) of
13) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.20 Pain Relevance 0.12
Whether the interaction between GR and p38 MAPK accounts for nongenomic anti-inflammatory effects of glucocorticoids remains to be investigated.
GR Binding (interaction) of associated with inflammation
14) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.49 Pain Relevance 0.23
Glucocorticoids act by binding to a specific GR.
GR Binding (binding) of
15) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.17 Pain Relevance 0.10
The latter includes binding of GR to a DNA-bound activator (tethering mechanism) or formation of abortive complex between GR and another transcription factor (squelching mechanism) [78].
GR Binding (binding) of
16) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0 Pain Relevance 0.07
Upon activation, subsequent to ligand binding, the GR undergoes conformational changes, dissociation from other proteins (particularly shedding from hsps), dimerization, translocation to the nucleus and contact with general transcription factors, adapter proteins and various coactivators.
GR Binding (ligand) of in nucleus
17) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.16 Pain Relevance 0
Both endotoxin and lipopolysaccaride (LPS) have been shown to decrease GR affinity for ligand, mainly by inducing cytokine expression [53].
GR Binding (affinity) of associated with cytokine
18) Confidence 0.20 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.78 Pain Relevance 0.22
have been described, but the most common is transrepression, which involves inhibitory protein-protein interactions between GR?
GR Binding (interactions) of
19) Confidence 0.18 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.26 Pain Relevance 0.11
Accordingly, we presumed that the extract was capable of increasing the activities of GPx and GR, which resulted in enhanced intracellular glutathione cycling.
GR Binding (activities) of
20) Confidence 0.15 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3005810 Disease Relevance 0 Pain Relevance 0

General Comments

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