INT262330

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C19) endoplasmic reticulum (CYP2C19) Golgi apparatus (TRIP10)
enzyme binding (CYP2C19) cytoplasm (TRIP10) cytosol (TRIP10)
TRIP10 (Homo sapiens)
CYP2C19 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABA receptor 2 98.12 Very High Very High Very High
gABA 16 91.92 High High
carbamazepine 7 81.64 Quite High
anticonvulsant 6 64.96 Quite High
antiepileptic Drug 33 62.96 Quite High
nMDA receptor 3 62.12 Quite High
Lamotrigine 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Gabapentin 6 5.00 Very Low Very Low Very Low
deep brain stimulation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myoclonic Epilepsies 3 89.12 High High
Syndrome 140 82.72 Quite High
Epilepsy 97 78.84 Quite High
Convulsion 125 66.36 Quite High
Encephalopathy 1 31.12 Quite Low
Infantile Spasms 9 27.36 Quite Low
Hepatic Insufficiency 1 27.00 Quite Low
Toxicity 3 18.88 Low Low
Syncope 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical studies were based on the fact that STP also acts as a powerful inhibitor of CYP3A4, CYP1A2, and CYP2C19, but gave disappointing results in adult patients.
Positive_regulation (acts) of STP Negative_regulation (inhibitor) of CYP2C19
1) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.80 Pain Relevance 0.26

General Comments

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