INT262339

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.07
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TRIP10) cytoplasm (TRIP10) cytosol (TRIP10)
lipid binding (TRIP10) signal transduction (TRIP10) cytoskeleton (TRIP10)
Anatomy Link Frequency
neurons 1
corpus callosum 1
TRIP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 486 99.98 Very High Very High Very High
Central nervous system 10 98.44 Very High Very High Very High
Pain 139 98.16 Very High Very High Very High
GABA receptor 2 98.12 Very High Very High Very High
gABA 28 91.92 High High
Neurotransmitter 36 91.40 High High
GABAergic 24 90.76 High High
Sciatic nerve 12 86.32 High High
Calcium channel 57 84.76 Quite High
central sensitization 42 83.36 Quite High
Disease Link Frequency Relevance Heat
Nociception 360 100.00 Very High Very High Very High
Pain 265 98.16 Very High Very High Very High
Myoclonic Epilepsies 3 84.72 Quite High
Syndrome 158 82.72 Quite High
Depression 66 79.20 Quite High
Epilepsy 97 78.84 Quite High
Anaerobic Bacterial Infections 42 73.12 Quite High
Convulsion 125 66.36 Quite High
Hepatic Insufficiency 1 27.00 Quite Low
Encephalopathy 1 26.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus far, it appears that stimulation of any afferent to ACC induces STP and distinct forms of short-term synaptic plasticities in the cingulate neurons have been reported in studies of electrical stimulation of callosal inputs [66], the layer II/III junction [67], layer V [65], and the thalamocortical pathway [58,68].
Positive_regulation (induces) of STP in neurons associated with anterior cingulate cortex
1) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.08 Pain Relevance 0.70
These two observations together suggest that the MITN projection to ACC mediates the nociceptive STP.


Positive_regulation (mediates) of STP associated with nociception and anterior cingulate cortex
2) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.10 Pain Relevance 0.26
These studies indicated that STP is mediated by the residual calcium in presynaptic terminals which increases the number of quanta released by a second afferent pulse.
Positive_regulation (mediated) of STP
3) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.34 Pain Relevance 0.24
The hypothesis guiding our studies of the thalamocingulate circuit is that the nociceptive MITN input generates STP in ACC and may be a precursor to longer term pain processing events.


Positive_regulation (generates) of STP associated with nociception, pain and anterior cingulate cortex
4) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.46 Pain Relevance 0.39
This approach, however, does not allow for the differentiation of STP generated by presynaptic and/or postsynaptic mechanisms.
Positive_regulation (generated) of STP
5) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.22 Pain Relevance 0.33
This slice preparation has intact MITN-ACC path and corpus callosum (cc) stimulation can be used to compare STP induced from both sites (Fig. 4A).
Positive_regulation (induced) of STP in corpus callosum associated with anterior cingulate cortex
6) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.08 Pain Relevance 0.33
Clinical studies were based on the fact that STP also acts as a powerful inhibitor of CYP3A4, CYP1A2, and CYP2C19, but gave disappointing results in adult patients.
Positive_regulation (acts) of STP
7) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.79 Pain Relevance 0.26

General Comments

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