INT262340

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.45
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TRIP10) cytoplasm (TRIP10) cytosol (TRIP10)
lipid binding (TRIP10) signal transduction (TRIP10) cytoskeleton (TRIP10)
TRIP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 51 99.46 Very High Very High Very High
amygdala 2 98.04 Very High Very High Very High
Anterior cingulate cortex 162 91.56 High High
antiepileptic Drug 33 89.20 High High
Glutamate 22 87.28 High High
Thalamus 60 86.16 High High
Inflammation 22 84.72 Quite High
GABA receptor 2 83.04 Quite High
gABA 20 76.84 Quite High
depression 20 68.84 Quite High
Disease Link Frequency Relevance Heat
Pain 93 99.46 Very High Very High Very High
Syndrome 164 98.56 Very High Very High Very High
Nociception 120 97.92 Very High Very High Very High
Metastasis 1 97.16 Very High Very High Very High
Myoclonic Epilepsies 3 93.88 High High
INFLAMMATION 22 84.72 Quite High
Depression 22 68.84 Quite High
Epilepsy 97 63.76 Quite High
Encephalopathy 1 57.36 Quite High
Infantile Spasms 9 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This distribution of lysine residues is seen in protein structures that interact with inositolphosphate ligands, including Drosophila melanogaster amphiphysin (PDB code 1URU) , endophilin-A1 BAR domain (PDB code 1ZWW), CIP4 (Cdc42-interacting protein-4), F-BAR domain (PDB code 2EFK), and IMD domain from IRSp53/missing-in-metastasis (PDB code 1Y2O) [58]–[62].
Cdc42-interacting protein-4 Binding (interact) of associated with metastasis
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.10 Pain Relevance 0.06
Indeed, the homologous F-BAR domain of CIP4 interacts with microtubules [14] and the related N-BAR family member, amphiphysin, interacts with a linker protein (CLIP-170) that binds to microtubules [29].
CIP4 Binding (interacts) of
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
All levels of pain processing in the CNS are associated with STP.
STP Binding (associated) of associated with pain
3) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.46 Pain Relevance 0.49
Regulation of STP, especially PPF, has been associated with a migration of AMPA receptors [86].
STP Binding (associated) of
4) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0 Pain Relevance 0.17
It will be important to determine whether PSTPIP1 binds directly to microtubules, like the related F-BAR protein, CIP4 [14], or whether the interaction is via an intermediate microtubule binding protein, as in the case of amphiphysin [29].
CIP4 Binding (binds) of
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0.04
However, the interactions of STP with a large number of drugs or toxic endogenous products need to be carefully considered from a long term safety perspective.


STP Binding (interactions) of
6) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.81 Pain Relevance 0.20

General Comments

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