INT262344

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.60
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Lgsn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 2 99.84 Very High Very High Very High
carbamazepine 30 99.04 Very High Very High Very High
antiepileptic Drug 141 87.88 High High
gABA 64 86.96 High High
anticonvulsant 26 82.36 Quite High
nMDA receptor 12 79.52 Quite High
GABA receptor 8 75.28 Quite High
Glutamate 16 61.00 Quite High
Pyramidal cell 4 57.16 Quite High
potassium channel 4 55.68 Quite High
Disease Link Frequency Relevance Heat
Syndrome 605 100.00 Very High Very High Very High
Convulsion 539 100.00 Very High Very High Very High
Epilepsy 396 100.00 Very High Very High Very High
Cognitive Disorder 26 86.36 High High
Ketosis 4 77.84 Quite High
Autism 8 73.16 Quite High
Absence Epilepsy 14 64.04 Quite High
Disease 28 62.84 Quite High
Systemic Lupus Erythematosus 4 56.12 Quite High
Myoclonic Epilepsies 12 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A population analysis in 117 children (4–11 years) and 99 adolescents (12–17 years) determined that the pharmacokinetics of rufinamide were similar to those seen in adult studies. 23 In a pharmacokinetic study of 129 adults and children with LGS, a decrease in bioavailability was observed with higher doses in the children.
Negative_regulation (decrease) of LGS associated with syndrome and bioavailability
1) Confidence 0.37 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2951747 Disease Relevance 0.17 Pain Relevance 0.11
PHT can control tonic-clonic seizures and reduce tonic seizures in LGS, but aggravation of atypical absences and myoclonic seizures is common (Schmidt and Bourgeois 2000; Dulac 2001; Sazgar and Bourgeois 2005) and chronic use should, therefore, be avoided.
Negative_regulation (reduce) of LGS associated with convulsion and syndrome
2) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.88 Pain Relevance 0.28
The LGS study BC-274, a single blind triphasic study showed a decrease in fits in 72% of the 24 participants aged 1–22 years.
Negative_regulation (decrease) of LGS associated with syndrome
3) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.89 Pain Relevance 0.21
However, the global review of published cases suggests that IVIG might be effective in some patients with refractory epilepsy, including LGS (Orange et al 2006; Feasby et al 2007).


Spec (might) Negative_regulation (effective) of LGS associated with epilepsy and syndrome
4) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.74 Pain Relevance 0.06
Data on evolution and prognosis are, however, often contradictory, mainly due to different definitions of LGS not only over time but also in different countries.


Negative_regulation (definitions) of LGS associated with syndrome
5) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.92 Pain Relevance 0

General Comments

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