INT262347

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synaptic vesicle 1
Bri3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 4 79.12 Quite High
gABA 16 78.24 Quite High
anticonvulsant 6 35.72 Quite Low
antiepileptic Drug 33 30.48 Quite Low
Lamotrigine 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
carbamazepine 7 5.00 Very Low Very Low Very Low
Gabapentin 6 5.00 Very Low Very Low Very Low
deep brain stimulation 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 140 96.48 Very High Very High Very High
Epilepsy 97 95.48 Very High Very High Very High
Toxicity 3 88.72 High High
Hepatic Insufficiency 1 73.52 Quite High
Convulsion 125 42.12 Quite Low
Anorexia 1 27.16 Quite Low
Ataxia 3 26.44 Quite Low
Sleep Disorders 4 26.12 Quite Low
Syncope 10 5.00 Very Low Very Low Very Low
Infantile Spasms 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brivaracetam (BRI) possesses a binding affinity for the synaptic vesicle protein 2A (SV2A) that is ten-fold more powerful than LEV and also shows an ability to inhibit Na+ channels.
BRI Binding (affinity) of in synaptic vesicle
1) Confidence 0.02 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.70 Pain Relevance 0.08

General Comments

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