INT262364

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.44
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
nucleus accumbens 1
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 294 100.00 Very High Very High Very High
depression 234 99.98 Very High Very High Very High
Nucleus accumbens 28 99.44 Very High Very High Very High
addiction 4 97.64 Very High Very High Very High
Pain 6 97.20 Very High Very High Very High
imagery 86 79.60 Quite High
positron emission tomography 44 71.44 Quite High
Neurosurgical lesion 4 49.80 Quite Low
Thalamus 38 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 239 99.98 Very High Very High Very High
Anxiety Disorder 175 99.98 Very High Very High Very High
Disease 25 99.32 Very High Very High Very High
Syndrome 78 98.64 Very High Very High Very High
Stroke 1 98.20 Very High Very High Very High
Coma 1 97.88 Very High Very High Very High
Pain 5 97.20 Very High Very High Very High
Epilepsy 2 96.32 Very High Very High Very High
Convulsion 6 85.44 High High
Movement Disorders 41 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies included a total of 42 patients with OCD who were treated with DBS, 67 patients with TRD, and one with both OCD and TRD.
Positive_regulation (treated) of DBS associated with depression, deep brain stimulation and anxiety disorder
1) Confidence 0.39 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 1.07 Pain Relevance 0.47
Four treatment-resistant OCD patients with co-morbid severe anxiety disorder received DBS to the right nucleus accumbens.
Positive_regulation (received) of DBS in nucleus accumbens associated with nucleus accumbens, deep brain stimulation and anxiety disorder
2) Confidence 0.39 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.63 Pain Relevance 0.24
Improvement of these severely ill patients by chance has a very low probability and that the nature of DBS lends itself to using the patient as its own control, by simply turning off the stimulator, as there is usually no sensation from DBS.
Neg (no) Positive_regulation (sensation) of DBS associated with deep brain stimulation
3) Confidence 0.39 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.11 Pain Relevance 0.16
Sixteen studies published between 1999 and 2009 were selected for review: nine for OCD [4-12], seven for TRD [10,13-18], and one for both disorders [19] (in Jimenez et al., 2007 [10], one patient with OCD and another with TRD underwent DBS).
Positive_regulation (underwent) of DBS associated with deep brain stimulation, depression and anxiety disorder
4) Confidence 0.37 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 1.05 Pain Relevance 0.47
As has been reported for patients who have received DBS for Parkinson’s disease, HFS for TS may induce or exacerbate pre-existing psychiatric symptoms (Appleby et al 2007).


Positive_regulation (received) of DBS associated with deep brain stimulation, syndrome and disease
5) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.75 Pain Relevance 0.29
DBS is also being actively evaluated for application to other diseases including stroke, coma, addiction, pain, depression, and epilepsy.
Positive_regulation (evaluated) of DBS associated with pain, depression, stroke, disease, coma, addiction, epilepsy and deep brain stimulation
6) Confidence 0.14 Published 2010 Journal J Comput Neurosci Section Body Doc Link PMC2912982 Disease Relevance 0.82 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox