INT262375

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 12.37
Pain Relevance 10.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fmod) extracellular region (Fmod) proteinaceous extracellular matrix (Fmod)
intracellular (Fmod)
Anatomy Link Frequency
Impression 1
Fmod (Mus musculus)
Pain Link Frequency Relevance Heat
Fibrositis 693 100.00 Very High Very High Very High
Pain 360 99.98 Very High Very High Very High
pregabalin 720 99.58 Very High Very High Very High
Pain score 81 99.00 Very High Very High Very High
Duloxetine 126 98.76 Very High Very High Very High
Myofascial pain syndrome 9 96.24 Very High Very High Very High
withdrawal 54 95.92 Very High Very High Very High
headache 36 94.80 High High
Migraine 9 94.40 High High
Inflammation 27 93.92 High High
Disease Link Frequency Relevance Heat
Fibromyalgia 693 100.00 Very High Very High Very High
Pain 486 99.98 Very High Very High Very High
Anxiety Disorder 135 99.76 Very High Very High Very High
Depression 153 99.28 Very High Very High Very High
Convulsion 27 99.26 Very High Very High Very High
Depressive Disorder 9 98.16 Very High Very High Very High
Chronic Fatigue Syndrome 18 97.28 Very High Very High Very High
Restless Legs Syndrome 9 97.08 Very High Very High Very High
Pressure And Volume Under Development 45 96.80 Very High Very High Very High
Dysesthesia 9 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment goals include the improvement of symptoms, primarily pain and sleep, and the promotion of improvement of physical function, emotional well-being and other symptoms associated with FM.
FM Binding (associated) of associated with pain and fibrositis
1) Confidence 0.20 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 1.06 Pain Relevance 1.10
Duloxetine was an effective and safe treatment for many of the symptoms associated with FM in subjects with or without major depressive disorder, particularly for women, who had significant improvement across most outcome measures.
FM Binding (associated) of associated with depression, fibrositis and duloxetine
2) Confidence 0.20 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 1.45 Pain Relevance 0.85
FM is frequently associated with anxiety and depressive symptoms which are reported by approximately 1/3 of patients (Wolfe et al 1995; White et al 2002; Antai-Otong 2005).
FM Binding (associated) of associated with depression, anxiety disorder and fibrositis
3) Confidence 0.20 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 1.62 Pain Relevance 0.93
The evaluation of symptomatic relief of pain associated with FM was based on comparison of endpoint mean pain scores between each pregabalin group and placebo.
FM Binding (associated) of associated with pregabalin, pain, pain score and fibrositis
4) Confidence 0.20 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 1.20 Pain Relevance 1.33
FM is strongly associated with additional symptoms such as anxiety and depressive syndromes, chronic fatigue syndrome, myofascial pain syndrome, hypothyroidism, and many of the inflammatory rheumatic diseases (Aaron et al 2000; Mease 2005).
FM Binding (associated) of associated with chronic fatigue syndrome, anxiety disorder, myofascial pain syndrome, fibrositis, rheumatic diseases, depressive disorder, inflammation and thyroid disease
5) Confidence 0.20 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 3.08 Pain Relevance 1.57
The trial, performed in adults with FM and ?
FM Binding (adults) of associated with fibrositis
6) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 0.85 Pain Relevance 0.96
Another outcome variable, management of FM, included endpoint mean pain scores, Patient Global Impression of Change (PGIC), and the FIQ-Total Score.
FM Binding (management) of in Impression associated with pain score and fibrositis
7) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 1.14 Pain Relevance 1.29
Clinical studies have demonstrated that the anti-seizure drug pregabalin is effective in the treatment of FM and its related symptoms (Lyrica®; Owen 2007).
FM Binding (treatment) of associated with pregabalin, convulsion and fibrositis
8) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 0.92 Pain Relevance 0.97
The complexity of FM makes it challenging for pharmaceutical companies to mount effective clinical trials to assess emerging therapies.
FM Binding (complexity) of associated with fibrositis
9) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 1.05 Pain Relevance 1.09

General Comments

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