INT26239

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 8.86
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
blood 3
synovium 3
peripheral nerve 2
microglia 2
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 12 99.96 Very High Very High Very High
Spinal cord 6 99.16 Very High Very High Very High
COX-2 inhibitor 1 99.10 Very High Very High Very High
Peripheral nerve injury 3 98.24 Very High Very High Very High
allodynia 1 98.12 Very High Very High Very High
Pain 15 97.88 Very High Very High Very High
Inflammation 34 97.72 Very High Very High Very High
IPN 4 97.32 Very High Very High Very High
Neuropathic pain 4 96.92 Very High Very High Very High
antagonist 5 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 51 99.84 Very High Very High Very High
INFLAMMATION 41 99.70 Very High Very High Very High
Cerebral Malaria 30 98.96 Very High Very High Very High
Nervous System Injury 7 98.72 Very High Very High Very High
Neuropathic Pain 5 98.12 Very High Very High Very High
Pain 15 97.88 Very High Very High Very High
Inflammatory Pain 4 97.32 Very High Very High Very High
Hypersensitivity 6 95.40 Very High Very High Very High
Disease 26 94.44 High High
Hyperalgesia 12 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it is likely that nNOS protection against LT is actually mediated through local, transient and rapid NO gradients that cannot be compensated through nitrite therapy.
Positive_regulation (mediated) of Gene_expression (protection) of LT
1) Confidence 0.36 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.15 Pain Relevance 0.04
Though quercetin increased the production of LT, like the crude decoction it seems to affect bacterial metabolism as well.
Positive_regulation (increased) of Gene_expression (production) of LT
2) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2911405 Disease Relevance 0 Pain Relevance 0
Increased LT-Beta gene expression occurs in RA synovium and correlates with the degree of inflammation.
Positive_regulation (Increased) of Gene_expression (expression) of LT-Beta in synovium associated with inflammation and rheumatoid arthritis
3) Confidence 0.28 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.97 Pain Relevance 0.32
Nevertheless, here LT mRNA levels were not increased in ECM compared to uninfected controls.
Neg (not) Positive_regulation (increased) of Gene_expression (levels) of LT mRNA
4) Confidence 0.28 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.46 Pain Relevance 0.07
LT-Beta gene expression was significantly higher in RA patient synovial samples that were inflamed to a moderately severe degree compared to those inflamed to a minimal degree (P = 0.02).
Positive_regulation (higher) of Gene_expression (expression) of LT-Beta associated with rheumatoid arthritis
5) Confidence 0.21 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.91 Pain Relevance 0.28
The objective of this study was to investigate LT-Beta and LT-BetaReceptor (LT-BetaR) gene expression in RA patient synovium and blood samples compared with control individuals, and correlate with LT-Alpha and TNF-Alpha gene expression and disease parameters.
Spec (investigate) Positive_regulation (investigate) of Spec (investigate) Gene_expression (expression) of LT-Beta in blood associated with rheumatoid arthritis and disease
6) Confidence 0.21 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.56 Pain Relevance 0.17
It has been suggested that blockage of the cyclo-oxygenase enzyme by non-steroid anti-inflammatory drugs (NSAID) leads to increased production of LT via the lipoxygenase enzyme.
Positive_regulation (increased) of Gene_expression (production) of LT associated with inflammation and cinod
7) Confidence 0.09 Published 1989 Journal Scand. J. Rheumatol. Section Abstract Doc Link 2552571 Disease Relevance 0.49 Pain Relevance 0.49
The objective of this study was to investigate LT-Beta and LT-BetaReceptor (LT-BetaR) gene expression in RA patient synovium and blood samples compared with control individuals, and correlate with LT-Alpha and TNF-Alpha gene expression and disease parameters.
Spec (investigate) Positive_regulation (investigate) of in synovium Spec (investigate) Gene_expression (expression) of LT-Beta in blood associated with rheumatoid arthritis and disease
8) Confidence 0.07 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.56 Pain Relevance 0.17
It has been suggested that blockage of the cyclo-oxygenase enzyme by non-steroid anti-inflammatory drugs (NSAID) leads to increased production of LT via the lipoxygenase enzyme.
Positive_regulation (leads) of Gene_expression (production) of LT associated with inflammation and cinod
9) Confidence 0.06 Published 1989 Journal Scand. J. Rheumatol. Section Abstract Doc Link 2552571 Disease Relevance 0.49 Pain Relevance 0.49
Our findings suggest that the increase of LT synthesis in spinal microglia produced via p38 MAPK plays a role in the generation of neuropathic pain.
Positive_regulation (increase) of Gene_expression (synthesis) of LT in microglia associated with neuropathic pain
10) Confidence 0.06 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.03 Pain Relevance 0.67
Furthermore, we demonstrated that an increase in LT synthesis in microglia in the spinal cord induced by peripheral nerve injury contributes to neuropathic pain [14].
Positive_regulation (increase) of Gene_expression (synthesis) of LT in peripheral nerve associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
11) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 1.43 Pain Relevance 0.86
It has been postulated that ASA sensitivity may be caused by a mechanism with increased production of cysteinyl-LT (10) as the pathogenesis of AIA.
Positive_regulation (increased) of Gene_expression (production) of LT
12) Confidence 0.05 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779320 Disease Relevance 1.10 Pain Relevance 0.31
Lipoxygenase (5-LO) is the key enzyme for LT production.
Positive_regulation (enzyme) of Gene_expression (production) of LT
13) Confidence 0.04 Published 2002 Journal Viral Immunol. Section Abstract Doc Link 11952135 Disease Relevance 0.49 Pain Relevance 0.17
We have therefore investigated whether or not the selective COX-2 inhibitor NS-398, similar to indomethacin, stimulates leukotriene (LT) biosynthesis in rat peritoneal cells.
Spec (whether) Positive_regulation (stimulates) of Gene_expression (biosynthesis) of LT associated with cox-2 inhibitor
14) Confidence 0.04 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9657255 Disease Relevance 0.09 Pain Relevance 0.14
-LTX tetramer (which is induced in those conditions) is the only ?
Positive_regulation (induced) of Gene_expression (tetramer) of LTX
15) Confidence 0.03 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0.14 Pain Relevance 0.03

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