INT262395

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cer1) extracellular region (Cer1)
Anatomy Link Frequency
CER 2
Cer1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 116 99.44 Very High Very High Very High
Adenocarcinoma 26 97.04 Very High Very High Very High
Breast Cancer 2 50.00 Quite Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Ovarian Cancer 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding suggests that drug efflux pumps like P-glycoprotein mediate removal of both PTX and CER from the MDR tumor after 6 h, although, since only free drug is susceptible to efflux, we cannot conclude that the drugs must have been released from the nanoparticles by this time point.
Positive_regulation (mediate) of Negative_regulation (removal) of CER in CER associated with cancer
1) Confidence 0.17 Published 2008 Journal Molecular Pharmaceutics Section Body Doc Link PMC2646668 Disease Relevance 1.44 Pain Relevance 0

General Comments

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