INT262479

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
neurons 1
brain 1
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 8 97.88 Very High Very High Very High
sodium channel 4 93.84 High High
unmyelinated 4 87.44 High High
c fibre 2 86.40 High High
Glutamate receptor 3 83.76 Quite High
dorsal root ganglion 18 81.44 Quite High
Central nervous system 15 75.68 Quite High
tetrodotoxin 30 63.52 Quite High
Dopamine 3 48.04 Quite Low
Neurotransmitter 2 47.36 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 165 97.84 Very High Very High Very High
Ganglion Cysts 20 80.48 Quite High
Nociception 8 78.16 Quite High
Disease 17 76.64 Quite High
Neurodegenerative Disease 14 75.84 Quite High
Stress 11 52.28 Quite High
Pressure And Volume Under Development 8 12.80 Low Low
Death 31 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mammals, a family of Na+ channel ?
Phosphorylation (family) of Na
1) Confidence 0.06 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0.31 Pain Relevance 0.79
Analyses of brain Na+ channels have shown that the cytoplasmic loop between domains DI and DII of Na+ channels possesses several shared PKA and PKC phosphorylation sites [19–20].
Phosphorylation (phosphorylation) of Na in brain
2) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0.05 Pain Relevance 0.12
A recent study indicated that lack of tyrosine phosphorylation can inhibit the activity of Na+/K+-ATPase in cortical neurons, eventually resulting apoptosis [133].
Phosphorylation (phosphorylation) of Na in neurons associated with apoptosis
3) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

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