INT26248

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.42
Pain Relevance 9.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Anatomy Link Frequency
nucleus accumbens 1
dentate gyrus 1
lateral 1
forebrain 1
dorsal horn 1
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 30 100.00 Very High Very High Very High
Spinal cord 4 100.00 Very High Very High Very High
Dorsal horn 3 100.00 Very High Very High Very High
Dopamine 35 99.98 Very High Very High Very High
Buprenorphine 21 99.98 Very High Very High Very High
Enkephalin 3 99.82 Very High Very High Very High
fluoxetine 9 99.38 Very High Very High Very High
Nucleus accumbens 3 99.20 Very High Very High Very High
sSRI 3 99.14 Very High Very High Very High
opioid receptor 17 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 220 98.54 Very High Very High Very High
Drug Induced Neurotoxicity 2 77.28 Quite High
INFLAMMATION 4 76.96 Quite High
Toxicity 4 76.16 Quite High
Bordatella Infection 3 71.36 Quite High
Congenital Anomalies 44 65.84 Quite High
Nociception 1 64.12 Quite High
Opiate Addiction 4 56.72 Quite High
Disease 26 40.96 Quite Low
Holoprosencephaly 5 38.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further optimization using glycylglycine buffer found increased signal-to-noise ratio with inclusion of dithiothrietol, increased [35S]GTPgammaS incubation time (2-4 h) and guanosine 5'-diphosphate (GDP) preincubation (20-30 min), and use of [35S]GTPgammaS at 0.1 nM.
Positive_regulation (increased) of GTPgammaS
1) Confidence 0.40 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11430907 Disease Relevance 0 Pain Relevance 0.37
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Positive_regulation (stimulated) of GTP gamma S in nucleus accumbens associated with nucleus accumbens and buprenorphine
2) Confidence 0.36 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.79
Moreover, depending of the area analysed, the basal binding of [35S]GTPgammaS was differentially affected by this treatment: increased in DRN and decreased in hippocampal dentate gyrus.
Positive_regulation (increased) of GTPgammaS in dentate gyrus
3) Confidence 0.31 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18809415 Disease Relevance 0 Pain Relevance 0.84
GTP blocked GTP gamma S stimulation of IP3 formation in a concentration-dependent manner.
Positive_regulation (stimulation) of GTP gamma S
4) Confidence 0.25 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 3036863 Disease Relevance 0 Pain Relevance 0.04
Interestingly, the selective 5-HT re-uptake inhibitor (SSRI) fluoxetine had no effect on MDMA [(35)S]-GTPgammaS binding activation.
Positive_regulation (activation) of GTPgammaS associated with ssri and fluoxetine
5) Confidence 0.14 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17602794 Disease Relevance 0 Pain Relevance 0.40
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Positive_regulation (stimulated) of GTP gamma S in lateral associated with nucleus accumbens and buprenorphine
6) Confidence 0.12 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.79
In forebrain the A2AR agonist-stimulated [35S]GTPgammaS binding increases rapidly after P7, reaching its highest levels at P21 and then declining slightly to adult levels.
Positive_regulation (agonist-stimulated) of GTPgammaS in forebrain associated with agonist
7) Confidence 0.08 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.23
In all five groups, 1 microM of the mu-opioid receptor agonist [D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO) increased the guanosine-5'-O([35S]3'thio)triphosphate ([35S]GTPgammaS) binding activity on guanine nucleotide-binding (G) proteins, and 500 nM of GTPgammaS decreased the [3H]DAMGO binding affinity.
Positive_regulation (increased) of GTPgammaS associated with agonist, enkephalin and opioid receptor
8) Confidence 0.07 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10568511 Disease Relevance 0 Pain Relevance 0.48
The non-hydrolysable analogue of GTP, GTP-gamma-S, known to activate G-proteins, inhibited the Na+ current (INa).
Positive_regulation (activate) of GTP-gamma-S
9) Confidence 0.06 Published 1989 Journal Brain Res. Section Abstract Doc Link 2553201 Disease Relevance 0.07 Pain Relevance 0.16
HU210 significantly increased [35S]GTPgammaS binding in the dorsal horn of the spinal cord of both groups of rats compared with basal [35S]GTPgammaS binding; SR141716A blocked these effects.
Positive_regulation (increased) of GTPgammaS in dorsal horn associated with dorsal horn and spinal cord
10) Confidence 0.06 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886347 Disease Relevance 0.28 Pain Relevance 1.51
Ketamine and PCP, often used as selective NMDA receptor antagonists in animal models of schizophrenia, increase GTPgamma-S binding, a G-protein–activating protein.224,225 DA induction of [(35))S]GTP-gamma-S is markedly stimulated by BPA in prenatally and neonatally exposed male mice.174

Calbindin.

Positive_regulation (induction) of GTP-gamma-S associated with dopamine, nmda receptor antagonist, ketamine and schizophrenia
11) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.85 Pain Relevance 0.29
Lofentanil exhibited full agonism for enhancement of [35S]GTPgammaS binding to human recombinant ORL1 receptors (EC(50) 50 nM).
Positive_regulation (enhancement) of GTPgammaS
12) Confidence 0.00 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688973 Disease Relevance 0 Pain Relevance 1.57

General Comments

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