INT262511

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Aqp1) plasma membrane (Aqp1) nucleus (Aqp1)
cytoplasm (Aqp1)
Anatomy Link Frequency
neurons 2
Aqp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 39 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
potassium channel 9 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
Glutamate receptor 9 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 495 99.32 Very High Very High Very High
Stress 33 99.08 Very High Very High Very High
Toxicity 6 92.44 High High
Neurodegenerative Disease 42 85.28 High High
Diabetes Insipidus 3 37.60 Quite Low
Cancer 9 36.32 Quite Low
Pressure And Volume Under Development 24 36.00 Quite Low
Disease 51 35.20 Quite Low
Hypoxia 18 11.16 Low Low
Death 93 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although whether the increased AQP1 expression observed during hypertonic stress is an effect of direct water loss or a compensatory mechanism is not clear, the importance of AQP in cellular volume exchange is evident.
Positive_regulation (increased) of Gene_expression (expression) of AQP1 associated with stress
1) Confidence 0.37 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.47 Pain Relevance 0
Employing real-time PCR technique, our data demonstrated that cortical neurons induced to undergo apoptosis via lactacystin treatment showed increased AQP1 expression at 6 h (Fig. 1).
Positive_regulation (increased) of Gene_expression (expression) of AQP1 in neurons associated with apoptosis
2) Confidence 0.37 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.66 Pain Relevance 0
In fact the group showed that the reduction in ubiquitination occurred in parallel with an increase in total AQP1 protein expression.
Positive_regulation (increase) of Gene_expression (expression) of AQP1
3) Confidence 0.37 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.66 Pain Relevance 0

General Comments

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