INT262515

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Kcnj6, Bcl2) mitochondrion (Bcl2) transport (Kcnj6)
aging (Bcl2) growth (Bcl2) cell death (Bcl2)
Kcnj6 (Mus musculus)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 39.20 Quite Low
Neurotransmitter 2 38.80 Quite Low
Central nervous system 13 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 17 95.12 Very High Very High Very High
Death 31 94.08 High High
Injury 3 84.68 Quite High
Hypoxia 6 84.40 Quite High
Apoptosis 165 55.68 Quite High
Stress 11 40.68 Quite Low
Alzheimer's Dementia 4 39.56 Quite Low
Motor Neuron Diseases 1 26.36 Quite Low
Neurodegenerative Disease 14 23.52 Low Low
Parkinson's Disease 1 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistic events of how Mito-KATP exerts its protective effect has been unclear, but a recent study showed that activation of Mito-KATP by diazoxide increases the association of Bcl-2 with mitochondria, while prevents Bax translocation to mitochondria [74].


Positive_regulation (activation) of KATP Positive_regulation (increases) of Bcl-2 Binding (association) of
1) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.48 Pain Relevance 0

General Comments

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