INT262522

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Trp53, Foxo4) nucleus (Trp53, Foxo4) enzyme binding (Trp53, Foxo4)
cytoplasm (Trp53, Foxo4) cytosol (Trp53, Foxo4) cell cycle (Trp53, Foxo4)
Trp53 (Mus musculus)
Foxo4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 1 71.28 Quite High
Central nervous system 13 54.32 Quite High
ischemia 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 165 100.00 Very High Very High Very High
Neurodegenerative Disease 14 74.16 Quite High
Neuritis 1 71.28 Quite High
Necrosis 8 69.84 Quite High
Neurological Disease 1 39.36 Quite Low
Death 31 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is demonstrated in vitro that low endogenous K+ promotes binding of pro-apoptotic transcription factors p53 and Forkhead and hinders the transcription activity of anti-apoptotic factors e.g.
p53 Binding (binding) of Forkhead associated with apoptosis
1) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.70 Pain Relevance 0.10

General Comments

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