INT262545

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.39
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hspg2) extracellular region (Hspg2) proteinaceous extracellular matrix (Hspg2)
extracellular matrix organization (Hspg2)
Anatomy Link Frequency
neurons 2
internal 2
Hspg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 28 98.28 Very High Very High Very High
substance P 11 94.32 High High
calcitonin gene related peptide 14 94.16 High High
bradykinin 6 93.72 High High
Calcium channel 15 93.28 High High
Neuropeptide 2 93.16 High High
Thermal hyperalgesia 8 92.32 High High
Action potential 37 87.44 High High
Demyelination 3 86.88 High High
Inflammation 21 86.16 High High
Disease Link Frequency Relevance Heat
Injury 31 98.28 Very High Very High Very High
Nociception 26 95.56 Very High Very High Very High
Hyperalgesia 33 92.32 High High
Neuropathic Pain 50 90.40 High High
Demyelinating Disease 3 86.88 High High
INFLAMMATION 23 86.16 High High
Natriuresis 5 50.00 Quite Low
Sleep Disorders 2 14.88 Low Low
Hypertension 4 14.48 Low Low
Convulsion 1 10.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M U73122 before (5 min), during and after CCL2 application, the evoked calcium mobilization was significantly blocked (p < 0.05, n = 6 cells, Figure 3G) suggesting that activation of the PLC/IP3 pathways is necessary for the CCR2 function in DRG neurons from CCI rats.


Positive_regulation (necessary) of Positive_regulation (activation) of PLC in neurons associated with eae
1) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.81 Pain Relevance 0.43
DAG, generated by PLC activation, directly activates TRPC3/C6 [17].
Positive_regulation (generated) of Positive_regulation (activation) of PLC
2) Confidence 0.13 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores.
Positive_regulation (requires) of Positive_regulation (activation) of PLC in internal
3) Confidence 0.09 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.43
Increases in intracellular Ca2+ initiate several second messenger pathways including the activation of phospholipase A2 (PLA2), phospholipase C (PLC) and Ca2+-dependent kinases, which can lead to the generation of AA and its metabolites, release of Ca2+ from intracellular stores and phosphorylation of nociceptive ion channels, respectively.
Positive_regulation (lead) of Positive_regulation (activation) of PLC associated with nociception
4) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.57 Pain Relevance 0.55

General Comments

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