INT262546

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.30
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Calm3)
Anatomy Link Frequency
tail 2
Calm3 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 6 94.24 High High
agonist 13 78.16 Quite High
Pain 30 76.40 Quite High
addiction 6 76.40 Quite High
Neurotransmitter 17 72.08 Quite High
qutenza 74 63.44 Quite High
Action potential 12 62.48 Quite High
Neuropathic pain 2 48.80 Quite Low
Acute pain 1 47.20 Quite Low
IPN 3 45.64 Quite Low
Disease Link Frequency Relevance Heat
Calcification 2 99.08 Very High Very High Very High
Pain 38 76.40 Quite High
Rod Or Cone Dystrophy 2 62.68 Quite High
Night Blindness 18 59.36 Quite High
Channelopathies 34 50.00 Quite Low
Neuropathic Pain 6 48.80 Quite Low
Inflammatory Pain 3 45.64 Quite Low
Disease 32 44.12 Quite Low
Herpes Zoster 1 33.76 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 32.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This region also includes S800, the PKC phosphorylation site and overlaps with the 35 amino acid segment necessary for CaM binding.
Positive_regulation (necessary) of CaM Binding (binding) of
1) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.08 Pain Relevance 0.31
In wild-type Cav1.4, this intrinsic gating modulator resides within the C-terminal tail downstream of an IQ domain which is required for CaM binding (Figs. 5 and 6).
Positive_regulation (required) of CaM Binding (binding) of in tail
2) Confidence 0.05 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.12 Pain Relevance 0.04
Calcification of CaM at higher Ca2+ concentrations further stimulated CaM binding.
Positive_regulation (stimulated) of CaM Binding (binding) of associated with calcification
3) Confidence 0.05 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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