INT262549

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.60
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Nsa2) cellular_component (Nsa2) biological_process (Nsa2)
Nsa2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 32 99.76 Very High Very High Very High
Deafferentation 1 98.84 Very High Very High Very High
bradykinin 7 96.36 Very High Very High Very High
Thermal hyperalgesia 20 96.08 Very High Very High Very High
IPN 19 93.96 High High
qutenza 75 92.96 High High
Hyperalgesia 13 87.28 High High
Inflammation 53 84.80 Quite High
calcitonin gene related peptide 14 84.00 Quite High
cOX1 2 67.68 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 40 96.08 Very High Very High Very High
Inflammatory Pain 20 93.96 High High
Targeted Disruption 42 93.64 High High
INFLAMMATION 57 84.80 Quite High
Pain 52 52.44 Quite High
Colitis 2 52.24 Quite High
Nociception 18 51.12 Quite High
Pancreatitis 2 48.72 Quite Low
Clostridium Difficile Infection 1 47.12 Quite Low
Hemorrhage 2 39.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and an augmentation of the increase of IL-10 by 7-NINA and L-NAME may contribute to the mechanism by which pretreatment with 7-NINA and L-NAME reduces CFA-induced thermal hyperalgesia.
Localization (increase) of L-NAME associated with thermal hyperalgesia
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.22 Pain Relevance 0.39
However, the acid induced HCO3- secretion was inhibited by indothemacin, L-NAME, EP1 antagonist and sensory deafferentation but not by capsazepine [6].
Localization (secretion) of L-NAME associated with antagonist and deafferentation
2) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.39 Pain Relevance 1.09

General Comments

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