INT262558

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) transport (Trpv1) transmembrane transport (Trpv1)
lipid metabolic process (Trpv1) cytoplasm (Phax) cytosol (Trpv1)
Anatomy Link Frequency
spike 1
Phax (Rattus norvegicus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 148 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
Hippocampus 2 99.12 Very High Very High Very High
intrathecal 10 96.84 Very High Very High Very High
depression 2 95.96 Very High Very High Very High
Action potential 12 95.92 Very High Very High Very High
Pain 60 91.76 High High
Morphine 2 90.44 High High
Ventral tegmentum 2 82.40 Quite High
nociceptor 8 79.12 Quite High
Disease Link Frequency Relevance Heat
Nociception 32 99.20 Very High Very High Very High
Depression 2 95.96 Very High Very High Very High
Hypothermia 6 95.24 Very High Very High Very High
Increased Venous Pressure Under Development 12 94.60 High High
Osteogenic Sarcomas 2 92.92 High High
Pain 76 91.76 High High
Toxicity 4 83.92 Quite High
Death 2 79.88 Quite High
Hyperalgesia 14 69.12 Quite High
Urological Neuroanatomy 2 62.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RTX in very low (nanomolar) concentrations can activate TRPV1 slowly, maximally and irreversibly leading to depolarization beyond the threshold without generating action potentials.
RTX Positive_regulation (activate) of TRPV1 associated with action potential
1) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.74 Pain Relevance 0.79
TRPV1 activation by its agonists capsaicin, RTX and anandamide in the CA1 region of hippocampal slices resulted in the facilitation of paired pulse depression of spike potentials [7].
RTX Positive_regulation (activation) of TRPV1 in spike associated with depression, qutenza and agonist
2) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.52 Pain Relevance 1.14

General Comments

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