INT262572

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1)
protein complex (Mapk1) cytoplasm (Mapk1) cytosol (Mapk1)
Ngf (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 100.00 Very High Very High Very High
Lasting pain 7 99.92 Very High Very High Very High
qutenza 75 95.20 Very High Very High Very High
Cancer pain 1 93.08 High High
antagonist 31 89.32 High High
Pain 30 73.20 Quite High
substance P 11 57.60 Quite High
calcitonin gene related peptide 14 57.04 Quite High
Osteoarthritis 1 48.16 Quite Low
allodynia 1 47.40 Quite Low
Disease Link Frequency Relevance Heat
Pain 38 99.92 Very High Very High Very High
Cancer Pain 1 93.08 High High
Bone Cancer 1 92.88 High High
Targeted Disruption 16 59.76 Quite High
Nociception 16 50.88 Quite High
Lung Injury 1 50.52 Quite High
Burns 1 49.72 Quite Low
Osteoarthritis 1 48.16 Quite Low
Neuropathic Pain 6 47.40 Quite Low
INFLAMMATION 38 44.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest ERK and p38 MAPK pathways are required for optimal BMSC IL-6 induction by NGF and BDNF, with these pathways likely involved in baseline expression of IL-6 as a reduction in steady state expression was noted with both inhibitors in the absence of any neurotrophic stimulation.
NGF Positive_regulation (required) of ERK
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.11 Pain Relevance 0
NGF has been shown to sensitize TRPV1 by activating PLC and hydrolyzes PIP2, which tonically inhibits the channel [35, 139], or by activating PKC, PI3K [26, 35, 161, 167] and ERK [204].
NGF Positive_regulation (activating) of ERK associated with nerve growth factor
2) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.41 Pain Relevance 0.81

General Comments

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