INT262575

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1, Prkca) plasma membrane (Trpv1, Prkca) mitochondrion (Prkca)
transport (Trpv1) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
Anatomy Link Frequency
sensory neurons 1
Trpv1 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 6 99.08 Very High Very High Very High
qutenza 74 87.68 High High
Cannabinoid 1 67.84 Quite High
Neuropeptide 2 66.60 Quite High
calcitonin gene related peptide 14 63.00 Quite High
Hyperalgesia 5 58.72 Quite High
Inflammation 19 54.32 Quite High
Inflammatory mediators 4 36.96 Quite Low
agonist 13 33.68 Quite Low
Thermal hyperalgesia 2 27.60 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 7 58.72 Quite High
INFLAMMATION 21 54.32 Quite High
Nociception 16 24.24 Low Low
Pain 38 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Overactive Bladder 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various algesic agents like BK, ATP, trypsin and PGs are known to sensitize TRPV1 by activating PKC downstream of their G-protein coupled receptors in sensory neurons and in expressed systems.
TRPV1 Positive_regulation (activating) of PKC in sensory neurons associated with bradykinin
1) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.17 Pain Relevance 0.44

General Comments

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