INT262579

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Ngf (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 100.00 Very High Very High Very High
Lasting pain 7 99.92 Very High Very High Very High
qutenza 74 95.20 Very High Very High Very High
Cancer pain 1 93.08 High High
antagonist 31 89.32 High High
Pain 30 70.56 Quite High
substance P 11 54.96 Quite High
calcitonin gene related peptide 14 54.40 Quite High
Osteoarthritis 1 48.16 Quite Low
allodynia 1 47.40 Quite Low
Disease Link Frequency Relevance Heat
Pain 38 99.92 Very High Very High Very High
Cancer Pain 1 93.08 High High
Bone Cancer 1 92.88 High High
Nociception 16 48.24 Quite Low
Osteoarthritis 1 48.16 Quite Low
Neuropathic Pain 6 47.40 Quite Low
Coronary Artery Disease 2 29.20 Quite Low
Diabetes Mellitus 6 12.72 Low Low
Peripheral Neuropathy 2 12.00 Low Low
Increased Venous Pressure Under Development 6 9.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF has been shown to sensitize TRPV1 by activating PLC and hydrolyzes PIP2, which tonically inhibits the channel [35, 139], or by activating PKC, PI3K [26, 35, 161, 167] and ERK [204].
NGF Positive_regulation (activating) of PKC associated with nerve growth factor
1) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.36 Pain Relevance 0.80

General Comments

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