INT262580

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ngf, Hspg2) extracellular region (Ngf, Hspg2) signal transduction (Ngf)
proteinaceous extracellular matrix (Hspg2) extracellular matrix organization (Hspg2)
Ngf (Mus musculus)
Hspg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 100.00 Very High Very High Very High
Lasting pain 7 99.92 Very High Very High Very High
qutenza 74 95.20 Very High Very High Very High
Cancer pain 1 93.08 High High
antagonist 31 89.32 High High
Pain 30 63.36 Quite High
Osteoarthritis 1 48.16 Quite Low
substance P 11 47.76 Quite Low
allodynia 1 47.40 Quite Low
calcitonin gene related peptide 14 47.20 Quite Low
Disease Link Frequency Relevance Heat
Pain 38 99.92 Very High Very High Very High
Cancer Pain 1 93.08 High High
Bone Cancer 1 92.88 High High
Osteoarthritis 1 48.16 Quite Low
Neuropathic Pain 6 47.40 Quite Low
Nociception 16 41.04 Quite Low
Coronary Artery Disease 2 22.00 Low Low
Diabetes Mellitus 6 5.52 Low Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF has been shown to sensitize TRPV1 by activating PLC and hydrolyzes PIP2, which tonically inhibits the channel [35, 139], or by activating PKC, PI3K [26, 35, 161, 167] and ERK [204].
NGF Positive_regulation (activating) of PLC associated with nerve growth factor
1) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.35 Pain Relevance 0.72

General Comments

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