INT262581

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkca, Trpv1) plasma membrane (Prkca, Trpv1) transport (Trpv1)
mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
Anatomy Link Frequency
neuronal 2
Prkca (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 148 99.12 Very High Very High Very High
agonist 26 95.00 High High
bradykinin 12 93.48 High High
Cannabinoid 2 63.16 Quite High
Pain 60 62.88 Quite High
Neuropeptide 4 61.92 Quite High
calcitonin gene related peptide 28 58.32 Quite High
IPN 6 56.00 Quite High
Hyperalgesia 10 54.04 Quite High
Acute pain 2 52.32 Quite High
Disease Link Frequency Relevance Heat
Pain 76 62.88 Quite High
Inflammatory Pain 6 56.00 Quite High
Hyperalgesia 14 54.04 Quite High
INFLAMMATION 42 49.64 Quite Low
Neuropathic Pain 12 49.60 Quite Low
Nociception 32 19.56 Low Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low
Overactive Bladder 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKC-dependent phosphorylation of TRPV1 not only potentiates capsaicin- or proton-evoked responses but also reduces its temperature threshold for activation [39, 126, 168, 183].
PKC Positive_regulation (dependent) of Phosphorylation (phosphorylation) of TRPV1 associated with qutenza
1) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.10 Pain Relevance 0.40
PKC-mediated phosphorylation of TRPV1 in DRG neuronal cultures has been shown to produce faster activation and slower deactivation of the channel [4].
PKC Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1 in neuronal
2) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.17 Pain Relevance 0.32

General Comments

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