INT262588

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.64
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Renbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 110 55.88 Quite High
cytokine 24 43.24 Quite Low
Inflammatory response 6 39.36 Quite Low
fibrosis 10 13.08 Low Low
Glutamate 58 9.12 Low Low
ischemia 26 5.00 Very Low Very Low Very Low
Abeta 24 5.00 Very Low Very Low Very Low
nMDA receptor 18 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 14 99.04 Very High Very High Very High
Diabetic Angiopathy 2 97.28 Very High Very High Very High
Diabetes Mellitus 50 96.40 Very High Very High Very High
Increased Venous Pressure Under Development 20 95.68 Very High Very High Very High
Toxicity 4 93.32 High High
Stress 72 90.56 High High
Esophageal Cancer 2 87.88 High High
Cancer 64 84.84 Quite High
Metastasis 6 84.44 Quite High
Glioma 6 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, blocking AGE-RAGE interactions leads to diminished cell growth [186].
Negative_regulation (blocking) of AGE Binding (interactions) of
1) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.37 Pain Relevance 0.05
Nitric Oxide donors can scavenge free radicals and inhibit AGE formation [163].
Negative_regulation (inhibit) of AGE Binding (formation) of
2) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.52 Pain Relevance 0
An important pharmacological strategy for the inhibition of this process utilises the small nucleophilic hydrazine compound aminoguanidine, which is a potent inhibitor of AGE mediated crosslinking [15].
Negative_regulation (inhibitor) of AGE Binding (crosslinking) of
3) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.30 Pain Relevance 0
To date there have been a range of approaches which seek to either prevent AGE formation, reduceAGE effects on cells, or even break established AGE crosslinks.
Negative_regulation (prevent) of AGE Binding (formation) of
4) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.45 Pain Relevance 0

General Comments

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