INT262618

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) endoplasmic reticulum (SOAT1)
plasma membrane (Kras) GTPase activity (Kras) transferase activity, transferring acyl groups (SOAT1)
SOAT1 (Homo sapiens)
Kras (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 97.76 Very High Very High Very High
rheumatoid arthritis 1 75.36 Quite High
fibrosis 1 71.92 Quite High
diabetic neuropathy 1 26.48 Quite Low
Glutamate 29 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 98.64 Very High Very High Very High
Disease Progression 3 79.68 Quite High
Diabetes Mellitus 13 77.84 Quite High
Disease 9 76.08 Quite High
Aging 4 76.08 Quite High
Rheumatoid Arthritis 1 75.36 Quite High
Pulmonary Fibrosis 1 72.72 Quite High
Cancer 1 70.16 Quite High
Neurodegenerative Disease 5 50.00 Quite Low
Age-related Macular Degeneration 8 29.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AGE receptor binding can initiate important signalling pathways involving activation of protein kinase C [108, 165], tyrosine phosphorylation of Janus kinase (JAK)/signal transducers and activators of transcription (STAT) [66], recruitment of phosphotidylinositol 3' kinase to Ras, [30] and induction of oxidative stress cascades which lead toNF?
STAT Binding (recruitment) of Ras associated with stress and kinase c
1) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.81 Pain Relevance 0.12

General Comments

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