INT262640

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.29
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA1) mRNA processing (AICDA) Golgi apparatus (HLA-DQA1)
endoplasmic reticulum (HLA-DQA1) plasma membrane (HLA-DQA1) cytoplasm (AICDA)
Anatomy Link Frequency
NK cell 1
HLA-DQA1 (Homo sapiens)
AICDA (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 48 95.80 Very High Very High Very High
rheumatoid arthritis 28 92.68 High High
Central nervous system 4 32.84 Quite Low
chemokine 4 10.60 Low Low
cytokine 4 10.00 Low Low
Inflammation 4 8.72 Low Low
spinal inflammation 32 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 180 100.00 Very High Very High Very High
Disease 92 100.00 Very High Very High Very High
Bacterial Infection 4 99.36 Very High Very High Very High
Diabetes Mellitus 68 97.40 Very High Very High Very High
Demyelinating Disease 48 95.80 Very High Very High Very High
Rheumatoid Arthritis 28 92.68 High High
Viral Infection 8 88.40 High High
Systemic Lupus Erythematosus 24 87.20 High High
Disease Susceptibility 16 29.92 Quite Low
INFLAMMATION 4 8.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA class I molecules could also be associated with AID due to their role in inhibiting NK cell activity.
HLA class I Binding (associated) of AID in NK cell associated with autoimmune disease
1) Confidence 0.03 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.79 Pain Relevance 0.05
Statistical modelling techniques, including logistic regression analysis, have been employed to determine which components of the DRB1-DQB1-DQA1 haplotype contain the etiological variants associated with AID.
DQA1 Binding (associated) of AID associated with autoimmune disease
2) Confidence 0.03 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.34 Pain Relevance 0.06
The observation, therefore, of a number of different DR and/or DQ associations, with AID suggests that there are common and unique disease pathways for each AID which may, in part, be explained by the presentation of different disease-specific autoantigens [1].


DQ Binding (associations) of AID associated with autoimmune disease and disease
3) Confidence 0.03 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.59 Pain Relevance 0.05
The observation, therefore, of a number of different DR and/or DQ associations, with AID suggests that there are common and unique disease pathways for each AID which may, in part, be explained by the presentation of different disease-specific autoantigens [1].


DQ Binding (associations) of AID associated with autoimmune disease and disease
4) Confidence 0.03 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.57 Pain Relevance 0.05

General Comments

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