INT262689

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 89.68 High High
Nerve growth factor 2 76.96 Quite High
ischemia 10 18.48 Low Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Nav1.1 6 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 52 93.56 High High
Disease 306 90.80 High High
INFLAMMATION 26 89.68 High High
Hypoxia 28 88.24 High High
Brain Injury 10 87.88 High High
Neurodegenerative Disease 4 84.40 Quite High
Neuroblastoma 2 82.96 Quite High
Increased Venous Pressure Under Development 10 80.80 Quite High
Injury 8 74.96 Quite High
Alzheimer's Dementia 44 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for altered BACE1 degradation first came from Puglielli and colleagues who reported that the lipid second messenger, ceremide, increases BACE1 half-life and the generation of A?
Regulation (altered) of Protein_catabolism (degradation) of BACE1
1) Confidence 0.53 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.28 Pain Relevance 0.04
BACE1 activity is also affected by the microenvironment, being stimulated by various lipid moieties [219], and the stability of BACE1 may be affected by ischemic conditions [185].
Spec (may) Regulation (affected) of Protein_catabolism (stability) of BACE1
2) Confidence 0.27 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.53 Pain Relevance 0.04

General Comments

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