INT262707

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace2, Bace1) peptidase activity (Bace2, Bace1) Golgi apparatus (Bace2, Bace1)
endoplasmic reticulum (Bace2, Bace1) enzyme binding (Bace1)
Bace2 (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 1 44.08 Quite Low
Neuronal excitability 1 39.76 Quite Low
Inflammation 11 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Nav1.1 3 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 31 76.08 Quite High
Cognitive Disorder 13 69.36 Quite High
Alzheimer's Dementia 22 13.84 Low Low
Disease 153 5.00 Very Low Very Low Very Low
Stress 26 5.00 Very Low Very Low Very Low
Syndrome 15 5.00 Very Low Very Low Very Low
Hypoxia 14 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Amyloid Plaque 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, mimicking the unique P2’-P4’ conformation of the bound inhibitor may increase the selectivity of inhibitors for BACE1 over BACE2 and the other aspartic proteases.


BACE2 Spec (may) Positive_regulation (increase) of BACE1
1) Confidence 0.33 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0

General Comments

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