INT262713

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (App, Bace1) endosome (Bace1) endoplasmic reticulum (Bace1)
enzyme binding (Bace1) extracellular matrix organization (App) DNA binding (App)
App (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 11 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Nav1.1 3 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 153 85.28 High High
Aging 5 80.88 Quite High
Targeted Disruption 31 72.32 Quite High
Urological Neuroanatomy 2 48.84 Quite Low
Contagious Ecthyma 2 8.16 Low Low
Stress 26 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 22 5.00 Very Low Very Low Very Low
Syndrome 15 5.00 Very Low Very Low Very Low
Hypoxia 14 5.00 Very Low Very Low Very Low
Cognitive Disorder 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that Tg2576 mice overexpress human APP with the Swedish mutation, Zohar and colleagues speculated that it was this APP overexpression in Tg2576 mice that effected the differential expression of BACE1 splice variants in these animals and suggested that APP may exert a regulatory role on BACE1 transcripts.
APP Regulation (role) of Transcription (transcripts) of BACE1
1) Confidence 0.45 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.31 Pain Relevance 0

General Comments

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