INT262729

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHN1)
Anatomy Link Frequency
fingers 3
stem 1
CHN1 (Homo sapiens)
RN7SL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 16 5.00 Very Low Very Low Very Low
Potency 16 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 56 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since NC binds with the SL2 loop mainly through its zinc fingers, and since NC and NC(11–55) exhibit similar binding constants to ODNs (50,73), we reasonably assume that the two proteins bind similarly to SL2.
NC Binding (binds) of SL2 in fingers
1) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Figure 6.3D structure of NC complexes with SL2 (A); d(ACGCC) (B) and (?)
NC Binding (complexes) of SL2
2) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Figure 6.3D structure of NC complexes with SL2 (A); d(ACGCC) (B) and (?)
NC Binding (complexes) of SL2
3) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Since NC binds with the SL2 loop mainly through its zinc fingers, and since NC and NC(11–55) exhibit similar binding constants to ODNs (50,73), we reasonably assume that the two proteins bind similarly to SL2.
NC Binding (binds) of SL2 in fingers
4) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
To strengthen this conclusion, these spectral changes were further related to the known structure of the full-length NC protein bound to SL2.
NC Binding (bound) of SL2
5) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Figure 5.Changes in the absorption (left) and emission (right) spectra of 3HC-NC(11–55) on binding to SL2 RNA.
NC Binding (binding) of SL2 RNA
6) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Since NC binds with the SL2 loop mainly through its zinc fingers, and since NC and NC(11–55) exhibit similar binding constants to ODNs (50,73), we reasonably assume that the two proteins bind similarly to SL2.
NC Binding (binds) of SL2 in fingers
7) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
The strongest changes were observed with the SL2 stem-loop, which binds strongly NC at the level of its loop (52).
NC Binding (binds) of SL2 in stem
8) Confidence 0.02 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0

General Comments

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