INT262753

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MTOR, PIK3CG) cytosol (MTOR, PIK3CG) mitochondrion (MTOR)
Golgi apparatus (MTOR) endoplasmic reticulum (MTOR) signal transduction (MTOR)
MTOR (Homo sapiens)
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 15.72 Low Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 38 94.48 High High
Solid Tumor 6 91.36 High High
Diabetes Mellitus 2 80.56 Quite High
Hyperglycemia 2 79.60 Quite High
Diarrhoea 6 74.80 Quite High
Appetite Loss 4 74.00 Quite High
Fatigue 9 72.88 Quite High
Pressure And Volume Under Development 2 68.96 Quite High
Fever 5 68.04 Quite High
Skin Cancer 11 50.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI3K, AKT, and mTOR have been targeted individually by various drugs, but XL765 is the first oral dual PI3K and mTOR inhibitor with Phase I trial results, reported by Papadopoulos et al [25].
mTOR Binding (targeted) of PI3K
1) Confidence 0.20 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.82 Pain Relevance 0

General Comments

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