INT262755

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MRGPRF, NFE2L2) cytosol (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2) signal transducer activity (MRGPRF)
MRGPRF (Homo sapiens)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 2 78.84 Quite High
Bioavailability 1 53.16 Quite High
positron emission tomography 4 50.40 Quite High
headache 4 31.76 Quite Low
Inflammation 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 38 98.72 Very High Very High Very High
Skin Cancer 11 85.44 High High
Thrombocytopenia 1 81.84 Quite High
Death 4 79.28 Quite High
Peripheral Neuropathy 2 78.84 Quite High
Anaemia 2 77.16 Quite High
Fatigue 9 76.84 Quite High
Solid Tumor 6 70.80 Quite High
Vomiting 6 70.00 Quite High
Toxicity 8 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, RTA 402 induces nuclear erythroid 2 p45 related factor (Nrf-2)-mediated transcription of antioxidant proteins which helps suppress tumor proliferation [35].
RTA Positive_regulation (induces) of Nrf-2 associated with cancer
1) Confidence 0.18 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.24 Pain Relevance 0.09

General Comments

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