INT262757

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SMO, GLI1) Golgi apparatus (SMO) intracellular (GLI1)
DNA binding (GLI1) cilium (SMO) signal transducer activity (SMO)
Anatomy Link Frequency
Skin 2
SMO (Homo sapiens)
GLI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 4 77.04 Quite High
headache 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 38 96.64 Very High Very High Very High
Gastrointestinal Neoplasms 1 73.32 Quite High
Toxicity 8 60.48 Quite High
Disease 14 28.00 Quite Low
Colon Cancer 6 19.76 Low Low
Skin Cancer 11 18.24 Low Low
Reprotox - General 1 2 15.20 Low Low
Fatigue 9 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low
Solid Tumor 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Skin punch biopsies were used to illustrate down-regulation of Gli1, a transcription factor activated by SMO, the target of GDC-0449.
SMO Positive_regulation (activated) of Regulation (regulation) of Gli1 in Skin
1) Confidence 0.34 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

This test has worked.

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