INT262779

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
extracellular matrix 1
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 47.36 Quite Low
peripheral neuropathy 2 44.96 Quite Low
positron emission tomography 4 26.08 Quite Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 48 99.82 Very High Very High Very High
Colon Cancer 13 96.72 Very High Very High Very High
Lung Cancer 2 95.56 Very High Very High Very High
Disease 18 90.88 High High
Cancer 157 88.28 High High
Reprotox - General 1 60 81.60 Quite High
Hyperglycemia 2 76.24 Quite High
Apoptosis 59 74.80 Quite High
Breast Cancer 23 73.20 Quite High
Diabetes Mellitus 2 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The annealed oligos in FAK RNAi2 plasmid were:
Localization (plasmid) of FAK
1) Confidence 0.71 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.07 Pain Relevance 0
Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase located in the cytoplasm at focal adhesions – sites that link the extracellular matrix to the cytoplasmic cytoskeleton.
Localization (located) of FAK in extracellular matrix associated with adhesions
2) Confidence 0.39 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.31 Pain Relevance 0
Though the exact pharmacologic mechanism by which genistein induces changes in cell adhesion is not known, we have shown that genistein increases FAK translocation to the focal adhesion complexes [120].
Localization (translocation) of FAK associated with adhesions
3) Confidence 0.20 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 1.37 Pain Relevance 0

General Comments

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