INT262797

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.27
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) DNA binding (Smad3)
protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)
Anatomy Link Frequency
plaques 2
Smad3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 101 92.08 High High
metalloproteinase 19 81.60 Quite High
fibrosis 4 78.00 Quite High
cytokine 25 62.72 Quite High
chemokine 20 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 144 99.74 Very High Very High Very High
Cataract 68 99.04 Very High Very High Very High
Infection 2 96.24 Very High Very High Very High
INFLAMMATION 108 92.08 High High
Emphysema 22 91.32 High High
Wound Healing 1 89.60 High High
Stress 23 78.56 Quite High
Fibrosis 5 78.00 Quite High
Sprains And Strains 2 76.68 Quite High
Inflammatory Bowel Disease 2 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SMA expression is not Smad3-dependent in that Smad3 deficient mice can develop small ASC plaques that are ?
Regulation (dependent) of Gene_expression (deficient) of Smad3 in plaques associated with cataract
1) Confidence 0.34 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2647562 Disease Relevance 0.97 Pain Relevance 0.04
1, Smad6 and Smad7, was observed to be decreased both in bronchial and alveolar tissue from patients with COPD, whereas in expression of stimulatory Smad molecules including Smad3 was unaltered (Springer et al 2004; Zandvoort et al 2006).
Regulation (unaltered) of Gene_expression (expression) of Smad3 associated with pulmonary disease
2) Confidence 0.10 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.30 Pain Relevance 0.21

General Comments

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