INT26280

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Context Info
Confidence 0.52
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.05
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 12
neurons 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 20 100.00 Very High Very High Very High
epidural 4 100.00 Very High Very High Very High
analgesia 3 100.00 Very High Very High Very High
neuropeptide release 1 100.00 Very High Very High Very High
Endogenous opioid 8 99.98 Very High Very High Very High
antagonist 6 99.78 Very High Very High Very High
noradrenaline 6 99.20 Very High Very High Very High
mu opioid receptor 1 99.12 Very High Very High Very High
Intracerebroventricular 2 99.02 Very High Very High Very High
narcan 19 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 13 99.82 Very High Very High Very High
Weight Loss 4 99.74 Very High Very High Very High
Congenital Anomalies 5 95.06 Very High Very High Very High
Syndrome 4 94.10 High High
Nociception 1 88.72 High High
Infection 2 86.72 High High
Anxiety Disorder 6 86.16 High High
Eating Disorder 3 75.00 Quite High
Natriuresis 2 75.00 Quite High
Depression 1 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANF III had no effect on the basal plasma AVP and OXT concentrations, however, the peptide inhibited the plasma AVP and OXT elevation induced by hyperosmosis (intraperitoneal injection of 2.5% NaCl).
Negative_regulation (inhibited) of Positive_regulation (induced) of OXT in plasma
1) Confidence 0.52 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.15 Pain Relevance 0.17
Salt loading reduced the footshock-induced increase in plasma oxytocin concentrations and noradrenaline release in the supraoptic nucleus (SON).
Negative_regulation (reduced) of Positive_regulation (increase) of oxytocin in plasma associated with noradrenaline
2) Confidence 0.50 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16157455 Disease Relevance 0 Pain Relevance 0.29
Here we discuss the mechanisms involved, which include induction of central inhibitory opioid tone by the progesterone neurosteroid metabolite, allopregnanolone, and act to prevent activation of oxytocin neurons by inappropriate stimuli at the end of pregnancy.
Negative_regulation (prevent) of Positive_regulation (activation) of oxytocin in neurons associated with opioid
3) Confidence 0.43 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.23 Pain Relevance 0.21
The initial decrease in plasma oxytocin reversed, and 4 h after injection of bremazocine a 20-fold increase in the oxytocin level was seen.
Negative_regulation (decrease) of Positive_regulation (increase) of oxytocin in plasma
4) Confidence 0.42 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.19
In another experiment, in morphine-dependent rats given intravenous (i.v.) naloxone, intracerebroventricular (i.c.v.) oxytocin receptor antagonist injection reduced the increase of plasma oxytocin concentration (to 28-fold) compared with i.c.v. vehicle (62-fold increase).
Negative_regulation (reduced) of Positive_regulation (increase) of oxytocin in plasma associated with antagonist, narcan, intracerebroventricular and morphine
5) Confidence 0.42 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141071 Disease Relevance 0 Pain Relevance 0.82
In pregnancy, endogenous opioids inhibit enhanced basal and stressor-stimulated oxytocin neurone activity and secretion.
Negative_regulation (inhibit) of Positive_regulation (stressor-stimulated) of oxytocin associated with endogenous opioid
6) Confidence 0.38 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10718931 Disease Relevance 0.17 Pain Relevance 0.21
In pregnancy, endogenous opioids inhibit enhanced basal and stressor-stimulated oxytocin neurone activity and secretion.
Negative_regulation (inhibit) of Positive_regulation (enhanced) of oxytocin associated with endogenous opioid
7) Confidence 0.38 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10718931 Disease Relevance 0.17 Pain Relevance 0.21
In vehicle-pretreated rats, fluoxetine produced a dose-dependent reduction in the (+/-)8-OH-DPAT-induced increase in plasma ACTH and oxytocin levels.
Negative_regulation (reduction) of Positive_regulation (increase) of oxytocin in plasma
8) Confidence 0.30 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457269 Disease Relevance 0 Pain Relevance 0
The number of Fos immunoreactive nuclei was not restored after oxytocin injection, indicating that appropriate activation of oxytocin neurones is impaired by progesterone and also that there is a lack of stimulatory afferent drive.
Negative_regulation (impaired) of Positive_regulation (activation) of oxytocin
9) Confidence 0.29 Published 2000 Journal J. Reprod. Fertil. Section Abstract Doc Link 11058452 Disease Relevance 0 Pain Relevance 0.23
It was concluded that syndrome-specific vasopressin and oxytocin abnormalities occur that are not secondary to weight loss or moderate exercise; that weight loss or fluoxetine increases circulating vasopressin; that moderate exercise alters neurohypophysial vasopressin and oxytocin content; and that weight loss or exercise inhibits a fluoxetine-stimulated increase in DVC oxytocin.
Negative_regulation (inhibits) of Positive_regulation (increase) of oxytocin associated with weight loss, congenital anomalies, syndrome and fluoxetine
10) Confidence 0.23 Published 1993 Journal Brain Res. Section Abstract Doc Link 8101130 Disease Relevance 0.95 Pain Relevance 0.82
However, the stress-induced increase in plasma levels of ACTH, corticosterone, oxytocin, prolactin and renin were not inhibited by fluoxetine treatment.
Negative_regulation (inhibited) of Positive_regulation (increase) of oxytocin in plasma associated with stress and fluoxetine
11) Confidence 0.21 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650130 Disease Relevance 1.15 Pain Relevance 1.01
Thus, the decrease in neuropeptide release, particularly for oxytocin, induced by the activation of mu-opioid receptors in neurohypophysial terminals is mediated, at least in part, by a corresponding decrease in Ca2+ entry due to the inhibition of voltage-gated Ca2+ channels.
Negative_regulation (decrease) of Positive_regulation (induced) of oxytocin associated with mu opioid receptor and neuropeptide release
12) Confidence 0.12 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12899684 Disease Relevance 0.06 Pain Relevance 0.43
The responses of oxytocin (OXT) and prolactin (PRL) were more susceptible to epidural analgesia and were blocked at the C8-T2 level.
Negative_regulation (blocked) of Positive_regulation (responses) of OXT associated with epidural and analgesia
13) Confidence 0.06 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8638794 Disease Relevance 0.16 Pain Relevance 0.52

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