INT26281

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.31
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 2
uterine 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
narcan 8 99.84 Very High Very High Very High
Immobilon 1 99.12 Very High Very High Very High
antagonist 7 97.00 Very High Very High Very High
agonist 6 86.20 High High
Kappa opioid receptor 3 85.88 High High
potassium channel 1 82.20 Quite High
Action potential 1 79.80 Quite High
opioid receptor 1 61.84 Quite High
Disease Link Frequency Relevance Heat
Erectile Dysfunction 4 93.40 High High
Dysmenorrhea 2 27.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial decrease in plasma oxytocin reversed, and 4 h after injection of bremazocine a 20-fold increase in the oxytocin level was seen.
Negative_regulation (reversed) of Negative_regulation (decrease) of oxytocin in plasma
1) Confidence 0.43 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.19
Prevention by morphine of apomorphine and oxytocin responses was abolished by naloxone (3 mg/kg i.p.) given 15 min before morphine.
Negative_regulation (abolished) of Negative_regulation (Prevention) of oxytocin associated with narcan and morphine
2) Confidence 0.39 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9151298 Disease Relevance 0.31 Pain Relevance 0.80
Tetraethylammonium ions and 4-aminopyridine prevent opioid inhibition of neurohypophysial oxytocin release.
Negative_regulation (prevent) of Negative_regulation (inhibition) of oxytocin associated with opioid and immobilon
3) Confidence 0.36 Published 1987 Journal Brain Res. Section Title Doc Link 2829994 Disease Relevance 0 Pain Relevance 0.45
In conclusion, TT-235 may inhibit the uterine response to oxytocin by decreasing oxytocin receptor numbers and oxytocin binding affinity, which might explain the prolonged oxytocin antagonist activity of TT-235.
Negative_regulation (decreasing) of Negative_regulation (numbers) of oxytocin in uterine associated with antagonist
4) Confidence 0.35 Published 2004 Journal In Vivo Section Abstract Doc Link 15646817 Disease Relevance 0 Pain Relevance 0.12
Such infusions reduced the spontaneous activity of vasopressin but not oxytocin cells and reduced the proportion of cells displaying spontaneous phasic activity from 26% in vehicle-infused nuclei to 3% in U50, 488H-infused nuclei; this treatment also prevented acute inhibition of both vasopressin and oxytocin cells by U50,488H (1000 micrograms/kg, i.v.), confirming functional kappa-receptor downregulation.
Negative_regulation (prevented) of Negative_regulation (inhibition) of oxytocin
5) Confidence 0.15 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801385 Disease Relevance 0 Pain Relevance 0.35

General Comments

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