INT262819

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.66
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1) cytoskeleton (1190002H23Rik)
nucleus (1190002H23Rik) cell cycle (1190002H23Rik) cytoplasm (1190002H23Rik)
Anatomy Link Frequency
optic nerve 5
retina 1
Serpinf1 (Mus musculus)
1190002H23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 84.40 Quite High
ischemia 6 75.60 Quite High
cytokine 4 55.76 Quite High
ketamine 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 74 95.40 Very High Very High Very High
Aging 2 84.48 Quite High
INFLAMMATION 38 84.40 Quite High
Death 18 77.76 Quite High
Cv Unclassified Under Development 4 75.60 Quite High
Hypoxia 2 64.12 Quite High
Diabetes Mellitus 4 56.76 Quite High
Diabetic Retinopathy 6 52.76 Quite High
Ocular Hypertension 16 10.80 Low Low
Ganglion Cysts 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Gene_expression (transfection) of PEDF in optic nerve Negative_regulation (maintains) of RGC Binding (viability) of in optic nerve
1) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.33 Pain Relevance 0.21
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Gene_expression (transfection) of PEDF in optic nerve Negative_regulation (maintains) of RGC in retina Binding (viability) of in optic nerve
2) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.33 Pain Relevance 0.21

General Comments

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