INT26282
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The decrease in elastin was associated with an increase in the stiffness of the aortic wall (elastic modulus: 15.1 +/- 1.8 in VDN vs. 6.7 +/- 0.5 10(6) dyn cm(-2) in controls), an increase in end-systolic stress (central systolic aortic pressure: 152 +/- 6 in VDN vs. 136 +/- 2 mm Hg in controls) (at a normotensive mean pressure level) and left ventricular hypertrophy (heart weight/body weight 2.51 +/- 0.10 in VDN vs. 2.24 +/- 0.07 g kg(-1) in controls). | |||||||||||||||
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In an acellular model, cigarette smoke inhibits elastin cross-linking (Laurent et al 1983), while the transcription of lysyl oxidase, a key effector of elastin cross-linking is reduced in fetal rat lung fibroblasts exposed to cigarette smoke extract (Gao et al 2005). | |||||||||||||||
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Arteries become wider and less elastic (increased PWV) with advancing age as a consequence of the age-related reduction in arterial elastin and increase in collagen content [16]. | |||||||||||||||
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Decrease of elastin from the media could be expected to result in arterial stiffening. | |||||||||||||||
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In animal models, prolonged starvation leads to decreases in total lung protein content, connective tissue, hydroxyproline and elastin [10]. | |||||||||||||||
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The number of WBS was proportional to the infusion dose of opioid agonist. | |||||||||||||||
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Thus, at the highest infusion dose, the average number of WBS observed was greatest for DADLE (32.8), morphine (30.2) and sufentanil (25.0) while animals treated with DAMGO displayed a significantly less degree of opioid dependence (8.7). | |||||||||||||||
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decreased smooth muscle cell proliferation, decreased collagen and elastin | |||||||||||||||
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Collagen and elastin loss, maxillary alveolar hypoplasia, and decreased facial musculature lead to a drooped tip[41]. | |||||||||||||||
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