INT26282

Context Info Confidence 0.51 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 6.37 Pain Relevance 3.76

cell proliferation (ELN) extracellular region (ELN) proteinaceous extracellular matrix (ELN)

Anatomy Link Frequency musculature 1 connective tissue 1 smooth muscle cell 1 lung 1 heart 1 ELN (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 4 99.16 metalloproteinase 3 98.92 antagonist 3 98.76 Morphine 4 98.36 Opioid 12 98.32 MU agonist 2 98.32 addiction 8 98.00 Nicotine 10 96.80 withdrawal 4 96.40 Antinociceptive 2 94.84

Disease Link Frequency Relevance Heat Starvation 5 99.80 Eating Disorder 25 95.48 Opiate Addiction 8 95.08 Hypertension 6 94.56 Hypoxia 15 94.40 Rhinitis 127 94.08 INFLAMMATION 111 94.08 Mediastinal Emphysema 2 93.92 Left Ventricular Hypertrophy 3 93.48 Injury 7 93.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The decrease in elastin was associated with an increase in the stiffness of the aortic wall (elastic modulus: 15.1 +/- 1.8 in VDN vs. 6.7 +/- 0.5 10(6) dyn cm(-2) in controls), an increase in end-systolic stress (central systolic aortic pressure: 152 +/- 6 in VDN vs. 136 +/- 2 mm Hg in controls) (at a normotensive mean pressure level) and left ventricular hypertrophy (heart weight/body weight 2.51 +/- 0.10 in VDN vs. 2.24 +/- 0.07 g kg(-1) in controls).

Negative_regulation (decrease) of elastin in heart associated with stress, body weight, left ventricular hypertrophy and nicotine

1) Confidence 0.51 Published 1997 Journal J. Vasc. Res. Section Abstract Doc Link 9349732 Disease Relevance 0.88 Pain Relevance 0.41

In an acellular model, cigarette smoke inhibits elastin cross-linking (Laurent et al 1983), while the transcription of lysyl oxidase, a key effector of elastin cross-linking is reduced in fetal rat lung fibroblasts exposed to cigarette smoke extract (Gao et al 2005).

Negative_regulation (inhibits) of elastin in lung

2) Confidence 0.25 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.11 Pain Relevance 0

Arteries become wider and less elastic (increased PWV) with advancing age as a consequence of the age-related reduction in arterial elastin and increase in collagen content [16].

Negative_regulation (reduction) of elastin

3) Confidence 0.16 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 0.61 Pain Relevance 0.06

Decrease of elastin from the media could be expected to result in arterial stiffening.

Negative_regulation (Decrease) of elastin

4) Confidence 0.16 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 0.71 Pain Relevance 0.25

In animal models, prolonged starvation leads to decreases in total lung protein content, connective tissue, hydroxyproline and elastin [10].

Negative_regulation (decreases) of elastin in connective tissue associated with starvation

5) Confidence 0.14 Published 2010 Journal Patient Saf Surg Section Body Doc Link PMC2825503 Disease Relevance 1.21 Pain Relevance 0.04

The number of WBS was proportional to the infusion dose of opioid agonist.

Negative_regulation (number) of WBS associated with mu agonist

6) Confidence 0.06 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553435 Disease Relevance 0.26 Pain Relevance 1.50

Thus, at the highest infusion dose, the average number of WBS observed was greatest for DADLE (32.8), morphine (30.2) and sufentanil (25.0) while animals treated with DAMGO displayed a significantly less degree of opioid dependence (8.7).

Negative_regulation (number) of WBS associated with addiction, opioid and morphine

7) Confidence 0.06 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553435 Disease Relevance 0.33 Pain Relevance 1.44

decreased smooth muscle cell proliferation, decreased collagen and elastin

Negative_regulation (decreased) of elastin in smooth muscle cell

8) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 1.33 Pain Relevance 0

Collagen and elastin loss, maxillary alveolar hypoplasia, and decreased facial musculature lead to a drooped tip[41].

Negative_regulation (loss) of elastin in musculature

9) Confidence 0.02 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2885381 Disease Relevance 0.92 Pain Relevance 0.06

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