INT262822

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1) cytoskeleton (1190002H23Rik)
nucleus (1190002H23Rik) cell cycle (1190002H23Rik) cytoplasm (1190002H23Rik)
Serpinf1 (Mus musculus)
1190002H23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 90.56 High High
Multiple sclerosis 4 88.32 High High
cytokine 4 9.52 Low Low
ischemia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 2 91.36 High High
INFLAMMATION 38 90.56 High High
Demyelinating Disease 4 88.32 High High
Necrosis 4 87.12 High High
Cancer 4 86.76 High High
Parkinson's Disease 2 86.72 High High
Alzheimer's Dementia 2 84.88 Quite High
Glaucoma 74 78.24 Quite High
Disease 6 65.12 Quite High
Stress 2 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that PEDF potently and efficaciously reduces RGC loss in DBA/2J mice, reduces expression of TNF and IL-18, and downregulates GFAP.
PEDF Negative_regulation (reduces) of Negative_regulation (loss) of RGC
1) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.82 Pain Relevance 0.07
Transduced PEDF potently and efficaciously reduces RGC loss and vision decline in DBA/2J mice, possibly via the reduction of TNF and IL-18, and downregulation of GFAP.
PEDF Negative_regulation (reduces) of Spec (possibly) Negative_regulation (loss) of RGC
2) Confidence 0.05 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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